(Mercola)—I’ve long warned about the dangers genetically modified organisms (GMOs) pose to human health and the environment, including the possibility of introducing new allergens into the food supply, decreasing biodiversity and increasing reliance on pesticides. Even more troubling is that the long-term health impacts of consuming GMOs remain largely unknown.

Despite these uncertainties, the biotechnology industry and Big Ag continue to push for widespread adoption of genetically modified (GM) crops, often downplaying their risks in favor of touted benefits. Now, a new threat looms over our food supply, as the U.S. Department of Agriculture (USDA) recently approved the first-ever cultivation of genetically modified wheat in the U.S.¹

While proponents described this decision as a “milestone” for the country’s agriculture, it has sparked strong opposition from scientists, environmental organizations and consumer advocates, who argue that this move prioritizes corporate interests at the expense of public health and environmental protection.²

USDA Gives Green Light to Controversial GM Wheat

The world’s first genetically modified wheat, HB4, was developed by the Argentine company Bioceres in collaboration with the French seed company Florimond Desprez. This strain is engineered to be drought-tolerant, and Bioceres claims it’s the only genetically modified wheat variety in the world with such technology.³

HB4 wheat is marketed as a solution to food security challenges, especially in drought-prone regions, where it claims to increase yields and reduce production costs for farmers. However, its cultivation relies heavily on the herbicide glufosinate ammonium, for which it has been engineered for increased tolerance. This chemical has been banned in several countries, including those in the European Union, due to its known health and environmental effects.⁴

The United States, one of the largest wheat producers in the world,⁵ is the fourth country to permit the production of HB4 wheat, along with Brazil, Argentina and Paraguay.⁶ While the USDA has concluded that HB4 can be safely grown and bred in the U.S. without posing significant risks to agriculture or the environment,⁷ consumer advocacy groups have pointed out that these claims are unfounded.

According to a report by Sustainable Pulse,⁸ there are several compelling reasons to question the safety and efficacy of GM wheat. First, there is no publicly available evidence demonstrating its safety for human health or the environment. The studies conducted by Bioceres are confidential, preventing independent scientists and the public from accessing or scrutinizing these findings.

Moreover, despite claims that HB4 wheat is drought-resistant, there are no independent studies to support this. In fact, Sustainable Pulse notes that available research indicates that this GM variety is less productive than conventional wheat, which means that its drawbacks could outweigh its purported benefits.

Argentina Has Become a Testing Ground for GM Wheat

While citizens in Argentina have the right to elect their leaders, they lack the ability to choose non-GMO food options because there is no labeling for genetically modified (GM) products. This allows a select group of individuals in influential positions within the government and scientific communities to make decisions that effectively force the entire population to consume GM products, leaving them with no alternative choices.

Since its approval in 2020, HB4 wheat has been widely cultivated across Argentina. Bioceres reported that by 2021, approximately 55,000 hectares of GM wheat had been harvested in the country.⁹ In the same year, the first shipment of flour made with GM wheat was exported to Brazil, the main export market for Argentinean wheat production.¹⁰

However, the process behind the approval and cultivation of GMOs in Argentina has been questionable. Sustainable Pulse’s report¹¹ points out that Argentina’s National Advisory Committee on Agricultural Biotechnology (CONABIA), which oversees GM approvals, is heavily influenced by the very corporations that produce GMOs.

This revolving door between government and corporate interests creates a conflict of interest, where those seeking approval are also involved in the decision-making process. Argentina’s National Scientific and Technical Research Council (CONICET) has ties with Bioceres as well, with its senior researcher, Raquel Chan, being involved in the development of GM wheat.

The lack of independent oversight is further compounded by the Argentine government’s reliance on confidential studies from these companies, with no independent research conducted to validate their findings. This has raised alarms in over a thousand scientists affiliated with CONICET and public universities, who have denounced the risks associated with GM wheat and its derivatives.

Widespread Opposition and Concerns Over GM Wheat Approval

There is a strong consensus against GM wheat among Argentinian farmers, indigenous groups and socio-environmental organizations.¹² The campaign “Con nuestro pan, no!” (which translates to “Not our bread!”) emphasizes that GM wheat is not a solution to hunger but rather a means to enhance the profits of the agro-industrial sector.¹³

The coalition also points out that Argentina’s experience with GM soy has yielded no tangible benefits for the public, questioning how GM wheat would be any different. Organizations across Latin America, Africa and Asia have also raised alarms about the dangers of GM wheat.¹⁴ Sustainable Pulse reported:¹⁵

“In a detailed 14-page document, social movements, peasants and indigenous people requested the intervention of United Nations (UN) special rapporteurs because of the risks to food, health and the environment posed by Bioceres’ GMO.

They confirmed that there are no independent studies confirming its harmlessness, denounced the dangerous herbicide glufosinate ammonium and also pointed out that it is less productive than conventional wheat.”

The small international nonprofit organization GRAIN has also voiced its opposition, condemning the irregular approval process for GM wheat in Argentina, Brazil and Paraguay, which, as stated, was based solely on studies provided by the manufacturer and confidential documentation.¹⁶

Health and Environmental Impacts of Glufosinate Ammonium

Glufosinate ammonium, the broad-spectrum herbicide used in the cultivation of HB4 wheat, works by inhibiting glutamine synthetase, an enzyme vital to plant growth.¹⁷ However, its impact is not limited to plants. The herbicide is classified as a neurotoxin, and long-term exposure has been linked to a variety of health issues in humans, including developmental, neurological and reproductive effects.¹⁸

Animal studies have shown that it interferes with the normal functioning of the nervous system¹⁹ and, in fetuses and infants exposed prenatally and perinatally, it has been linked to poor gut health,²⁰ behavioral abnormalities and motor function problems.²¹ This makes pregnant women and children particularly vulnerable to its harmful effects.

Beyond human health, the herbicide also poses significant risks to the environment. It contaminates soil and water sources, affecting non-target species. Aquatic organisms are especially susceptible, as runoff from fields treated with glufosinate pollutes nearby water bodies.^22,23 Despite these concerns, glufosinate ammonium continues to be used in the U.S. for controlling weeds.

The situation is further complicated by the increasing weed resistance to herbicides like glufosinate. As resistance grows, higher quantities of the herbicide are required for cultivation, exacerbating its health and environmental risks. This vicious cycle raises important questions about the sustainability of introducing yet another herbicide-reliant crop into U.S. agriculture.

Steer Clear of GMOs to Protect Your Health

Given these concerns, many health-conscious consumers are seeking ways to minimize exposure to GMOs and associated herbicides. The most effective approach is to make strategic changes to your diet. By prioritizing non-GMO, free-range and organic foods, you will significantly reduce your exposure to these harmful chemicals.

It’s important to be aware of common GMOs lurking in many processed foods without your knowledge. These include corn (often found in processed foods such as cornmeal, corn syrup, corn starch, corn flour, etc.), soy (which is sometimes listed as lecithin or starch, among others), canola and potato. By avoiding processed foods, you also reduce your intake of some of the most common inflammatory ingredients, including gluten, processed sugar and linoleic acid.

Additionally, it’s important to keep in mind that GMOs and pesticides also enter your diet through animal products. Many animals in concentrated animal feeding operations (CAFOs) are fed herbicide-resistant GE grains like corn and soy. This is one of several good reasons for making sure your meats come from organically raised, grass fed animals.

A Guide to Choosing Organic Food

For a product to be labeled as organic, it must be free from genetic engineering and grown without synthetic pesticides, herbicides or fertilizers.²⁴ Not all organic labels are the same, though. The U.S. Department of Agriculture (USDA) outlines four key classifications for consumers to be aware of:²⁵

• 100% organic — Products that have this label must be made with 100% certified organic ingredients. These items can display the USDA organic seal and make the “100% organic” claim.
• Organic — For a product to simply be labeled “organic,” at least 95% of its ingredients must be certified organic, with up to 5% nonorganic ingredients allowed, as long as they are listed on the National List of Allowed and Prohibited Substances.
• “Made with” organic ingredients — These items must contain at least 70% certified organic ingredients but cannot display the USDA organic seal or represent the entire product as organic.
• Specific organic ingredients — Products with less than 70% organic content cannot carry the organic seal or use the word “organic” on the packaging. However, certified organic ingredients can still be listed on the product’s ingredient panel.

Knowing these labels is just the first step. As the demand for organic products increases, some companies have tried to mislead consumers by falsely labeling conventionally grown products as “organic.” From 2020 to 2023, several farmers faced legal consequences for selling nonorganic produce as organic, with one case involving a staggering $71 million in fraud.²⁶

To protect yourself, it’s essential to be a vigilant consumer. Look beyond the label and research the sources of your organic products. The best way to find organic, chemical-free produce is to visit the farmers themselves. Shopping at farmers markets and talking directly to vendors provide valuable insights into their farming practices. Many of these small-scale operations prioritize sustainable methods and try their best to limit chemical use.

Additionally, consider joining a community-supported agriculture (CSA) program.²⁷ This subscription service allows you to receive regular deliveries of fresh produce from local farms that utilize sustainable agricultural practices. Some CSA farmers also offer educational programs to deepen your understanding of sustainable agriculture.

If you can’t join a CSA, the EWG’s “Dirty Dozen” list²⁸ will guide your shopping. This regularly updated list highlights the 12 fruits and vegetables most likely to be contaminated with pesticides, helping you make informed choices. Lastly, consider growing your own food using sustainable methods. By doing so, you’ll be able to ensure your food is as safe and chemical-free as possible.

Resources for Organic, Chemical-Free Produce

If you live in a dense, urban location in the U.S. that doesn’t have any local farmers markets, don’t worry. There are plenty of ways to connect with reputable organic farmers who employ regenerative agricultural practices so you will still be able to purchase their products. Below is a list of websites I recommend:

• American Grassfed Association — The goal of the American Grassfed Association (AGA) is to promote the grass fed industry through government relations, research, concept marketing and public education.

Their website also allows you to search for AGA-approved producers certified according to strict standards that include being raised on a diet of 100% forage; raised on pasture and never confined to a feedlot; never treated with antibiotics or hormones; born and raised on American family farms.

• EatWild.com — EatWild.com provides lists of farmers known to produce raw dairy products as well as grass fed beef and other farm-fresh produce (although not all are certified organic). Here you will also find information about local farmers markets, as well as local stores and restaurants that sell grass fed products.
• Weston A. Price Foundation — Weston A. Price has local chapters in most states, and many of them are connected with buying clubs in which you can easily purchase organic foods, including grass fed raw dairy products like milk and butter.
• Grassfed Exchange — The Grassfed Exchange has a listing of producers selling organic and grass fed meats across the U.S.
• Local Harvest — This website will help you find farmers markets, family farms and other sources of sustainably grown food in your area where you can buy produce, grass fed meats and many other goodies.
• Farmers Markets — A national listing of farmers markets.
• Eat Well Guide: Wholesome Food from Healthy Animals — The Eat Well Guide is a free online directory of sustainably raised meat, poultry, dairy and eggs from farms, stores, restaurants, inns, hotels and online outlets in the U.S. and Canada.
• Community Involved in Sustaining Agriculture (CISA) — CISA is dedicated to sustaining agriculture and promoting the products of small farms.
• The Cornucopia Institute — The Cornucopia Institute maintains web-based tools rating all certified organic brands of eggs, dairy products and other commodities, based on their ethical sourcing and authentic farming practices separating CAFO (concentrated animal feeding operation) “organic” production from authentic organic practices.
• RealMilk.com — If you’re still unsure of where to find raw milk, check out Raw-Milk-Facts.com and RealMilk.com. They will tell you what the status is for legality in your state, and provide a listing of raw dairy farms in your area. The Farm to Consumer Legal Defense Fund also provides a state-by-state review of raw milk laws.²⁹ California residents can also find raw milk retailers using the store locator available at RAW FARM.³⁰
• ^1, 7 USDA Animal and Plant Health Inspection Service, APHIS Issues Regulatory Status Review Responses: University of Florida and Bioceres Crop Solutions
• ^{2, 8, 11, 12, 14, 15} Sustainable Pulse, September 24, 2024
• ³ ISAAA Inc., October 14, 2020
• ⁴ Official Journal of the European Union, May 15, 2020
• ⁵ AgMRC, Wheat
• ⁶ ISAAA Inc., HB4 Wheat
• ⁹ Bioceres Crop Solutions, November 11, 2021
• ¹⁰ USDA Foreign Agricultural Service, December 8, 2023
• ¹³ Biodiversity Alliance, ¡Con nuestro pan NO!
• ¹⁶ GRAIN, January 30, 2024
• ¹⁷ Minnesota Department of Agriculture, Glufosinate Herbicide
• ¹⁸ Food and Agriculture Organization of the United Nations, Glufosinate (PDF)
• ¹⁹ NeuroToxicology Volume 69, December 2018, Pages 152-163
• ²⁰ J Hazard Mater. 2020 May 5:389:122152
• ²¹ Sci Rep. 2020 Nov 26;10(1):20647 (PDF)
• ²² Science of The Total Environment Volume 769, 15 May 2021, 144396
• ²³ Environmental Pollution Volume 296, 1 March 2022, 118742
• ²⁴ USDA, Organic 101: Can GMOs Be Used in Organic Products?
• ²⁵ USDA, Understanding the USDA Organic Label
• ²⁶ The Organic & Non-GMO Report, September 7, 2023
• ²⁷ GoodFoodCo., What Is CSA?
• ²⁸ EWG, Shopper’s Guide to Pesticides in Produce
• ²⁹ The Farm-to-Consumer Legal Defense Fund, State by State Review of Raw Milk Laws
• ³⁰ Raw Farm, Find Raw Dairy Products Near You

(Mercola)—According to the American Cancer Society, about 1 in 8 men will be diagnosed with prostate cancer during their lifetime. It’s the second-leading cause of cancer death behind lung cancer.¹ But despite its prevalence, a diagnosis is not an automatic death sentence.

Between 1993 and 2013, the death rate of prostate cancer declined by around half, and 3.3 million American men diagnosed with this disease at some point are still alive.² Furthermore, the National Cancer Institute predicts a 97.5% survival rate after diagnosis.³ But, we’re not out of the woods yet — plenty of research is still being done to learn more about treating this disease, and researchers from the University of Michigan have just pushed the frontier.

NSD2 Protein Implicated as an Activator of Prostate Cancer

In a study⁴ published in Nature Genetics, researchers discovered a key factor in the development of prostate cancer. Specifically, they noted that when the NSD2 (nuclear receptor binding SET Domain Protein 2) binds with the androgen receptor (AR), it leads to rapid cell division and growth that results in prostate cancer.

Before diving further into this, let’s define some of the basics. Androgens are essentially hormones that trigger the growth and development of the male reproductive system, and the most prominent example is testosterone. They’re responsible for the changes that males go through during puberty, such as thickening of the vocal cords that leads to a deeper voice.⁵

While androgens are largely associated with males, females produce androgens as well, but in smaller amounts. When androgens are released, they’re converted into estradiol, a type of estrogen. In this converted state, estradiol helps regulate menstruation, as well as conception and pregnancy.⁶

Now, what is the AR? It’s essentially a protein produced by the AR gene, which then binds to the androgens produced in your body. As noted by MedlinePlus:⁷

“The receptors are present in many of the body’s tissues, where they attach (bind) to androgens. The resulting androgen-receptor complex then binds to DNA and regulates the activity of certain genes that play a role in male sexual development. By turning the genes on or off as necessary, the androgen receptor complex helps direct the development of male sex characteristics.”

Going back to the Nature Genetics study,⁸ the researchers were able to crack the code, as it were, between NSD2 and AR using an epigenetics-targeted functional CRISPR (clustered regularly interspaced short palindromic repeats) screening. Interestingly, they noted that NSD2 is also an oncogene in hematologic cancers, and “harbors recurrent activating alterations in over 15% to 20% of multiple myeloma and 10% childhood acute lymphoblastic leukemia.”

Diving Deeper Into the Development of Prostate Cancer

The researchers used different methodologies that comprised human and animal test samples. For human samples, prostate tumor patient tissues were taken from the archives of University of Michigan archives, while mice were provided by the University of Pennsylvania and the University of Michigan, which were kept under humane conditions.⁹ After completing their assays and analysis, the researchers published these findings:¹⁰

“Conventional plasmid-based reporter systems fail to capture intricate epigenetic or chromatin-level regulation of gene expression as they lack the native histone composition or higher-order chromosomal structure. Thus, we engineered an endogenous AR reporter system by using the CRISPR/Cas9 and homologous recombination methodologies.

We edited the KLK3 gene (also known as prostate-specific antigen, PSA) locus in AR-driven LNCaP cells to knock-in the mCherry coding sequence directly downstream of the endogenous promoter and fused in-frame via an endopeptidase sequence to the KLK3 gene …

Using these endogenous AR reporter cell lines, we carried out a functional CRISPR screen, wherein we treated the cells with a custom single guide RNA (sgRNA) library targeting druggable transcriptional cofactors for eight days, stimulated with DHT for 16 h and FACS-sorted into mCherry^HIGH and mCherry^LOW populations.

Genomic sgRNAs were sequenced and the ratio of normalized counts in mCherry^LOW to mCherry^HIGH cell populations was used to rank individual sgRNAs. Here, ranked alongside BRD4 and TRIM24, we identified NSD2 as an AR coactivator.”

The study is packed with dense information largely meant for oncology researchers, but the findings above summarize how the researchers were able to sift through large swaths of information and methodologies. Undoubtedly, this new breakthrough will be beneficial for all people receiving prostate cancer treatments.

The researchers concluded that NSD2 plays an important role in the development of prostate cancer. Furthermore, they proposed targeting this protein in further experiments to fully confirm the effectiveness of their findings. In a press release, co-author Dr. Arul M. Chinnaiyan elucidates further:¹¹

“By degrading NSD1 and NSD2, we can more directly target cancer and avoid the normal tissue. Our study suggests if we’re able to develop NSD1/2-targeting agents, they could potentially be combined with FDA-approved androgen receptor antagonists and have a synergist effect in terms of treatment.”

Choline Does NOT Cause Prostate Cancer

Considering the new information published, I’d like to debunk a medical myth about prostate cancer that’s been circulating for a few years now — choline intake and its association with this disease.

The primary study where this notion came from,¹² published in 2012, suggested there might be a link between increased choline intake and an increased risk of advanced, lethal prostate cancer. As noted by the authors, “Men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer.” However, there are several questionable aspects surrounding this conclusion.

To start, the study was observational only, which means it only suggests associations but cannot prove causation. Since there are many factors, both dietary and environmental, that play a big role in predicting prostate cancer outcomes, pinning the disease to a single nutrient is problematic.

Furthermore, the researchers collected dietary information only six times during 22 years of follow-ups, which raises questions about the accuracy of their collated information. Many people can’t even recall what they ate several days ago, let alone the foods they consumed within a span of 22 years. Other shortcomings of this study include the following:

• It does not account for other components of the diet that could influence prostate cancer risk, such as phytonutrients, fiber and other vitamins and minerals.
• No dose-response relationship across quintiles of choline intake was established. Understanding whether the risk of prostate cancer increases linearly with choline intake or if there’s a threshold effect would be crucial for dietary recommendations.
• The study also looked at post-diagnostic intake of choline and its relationship with lethal prostate cancer among men who were initially diagnosed with nonmetastatic disease and here, no statistically significant link could be found.

In truth, choline is beneficial for your health. Several studies have shown that increasing choline intake has important benefits, such as decreased risk for heart disease,¹³ cancer¹⁴ and nonalcoholic fatty liver disease.¹⁵ Based on these findings, you’d be better off increasing your dietary choline intake, and the best sources include grass fed meat and milk, as well as pastured eggs.

Address the Root of Cancer — Poor Mitochondrial Health

I believe that virtually all major diseases like cancer, heart disease and obesity are linked to an inability to produce cellular energy due to impaired mitochondrial function. Without optimal cellular energy, your body cannot properly initiate the repair processes essential to preventing and recovering from disease.

Through the years, I’ve identified three pernicious toxins that damage your mitochondrial function, mainly by affecting intracellular calcium that subsequently impact your cellular health. In essence, exposure to these toxins raise intracellular calcium, which results in increased superoxide and nitric oxide levels. These combine into peroxynitrite, a potent reactive oxygen species that contributes to poor health. These three primary culprits are:

• Excess linoleic acid (LA) intake — An omega-6 polyunsaturated fat (PUFA), LA is abundantly found in seed and vegetable oils as well as ultraprocessed foods, and is one of most harmful ingredients in the Western diet. When consumed in excess, it negatively affects your metabolic rate and gut microbiome, which are the two of the most important factors that impact your health.
• Endocrine-disrupting chemicals (EDC) — Exposure to EDCs from sources like microplastics is over-activating your estrogen receptors. Microplastics are so pervasive that you’re probably eating a credit card’s worth of plastic every week.¹⁶ These plastics are loaded with phthalates and bisphenol A (BPA), which activate estrogen receptors. Estrogen increases intracellular calcium levels, which results in the generation of peroxynitrite.
• Excessive electromagnetic field (EMF) exposure — People are bombarded with EMFs, such as from cellphones, every day with hidden consequences to public health. EMFs activate voltage-gated calcium channel (VGCC) receptors within the cell, catalyzing the production of peroxynitrite by triggering an influx of calcium.

Addressing these three factors will help repair and return your mitochondrial function back on track to producing optimal cellular energy. Ultimately, this is the crucial first step to warding off all chronic disease that plague Americans today, such as cancer, and the best way to do it is limiting your exposure to them. To start, I recommend minimizing your LA intake below 5 grams from all dietary sources. If you can get it below 2 grams, that’s even better.

Next, minimize your EMF exposure by turning off the Wi-Fi and using hardwired connections instead. I also recommend using an analog alarm clock instead of relying on your phone’s alarm clock, which most people put beside their bed. The next strategy is reducing your exposure to plastics, which is accomplished by opting for products sold in glass containers and using reusable products over single-use ones.

This is just a preview of the strategies available to restore and repair your mitochondrial function. My newest book, “Your Guide to Cellular Health: Unlocking the Science of Longevity and Joy,” goes into great detail about how these three factors affect your mitochondrial function, as well as practical, healthy strategies to address them.

The eBook is now available, while the print edition will be released on December 10, 2024. I encourage you to pick up a copy, as this contains my latest research that corrects many long-held beliefs I’ve had in the previous years.

Another Anticancer Tip — Aspirin

In addition to addressing the main factors of mitochondrial function, there are other strategies available to help you prevent cancer. One approach is taking aspirin, a drug well-known for its pain-relieving and anti-inflammatory uses.

In my interview with bioenergetic medicine expert Georgi Dinkov, he discusses research using a combination of B vitamins and aspirin against a highly lethal form of human mantle cell lymphoma. He discovered that while the vitamins stopped tumor growth, adding aspirin into the equation regressed the tumor in the animal test subjects. Below, he explains the theoretical basis:

“One of Ray [Peat]’s main theories was that … cancer cells … [are] metabolically dysfunctional, we all know that, and typically a cell like that commits apoptosis. But in order to commit apoptosis, that mechanism is controlled almost entirely by the intracellular pH. And in order for apoptosis to occur, it needs to be in the acidic range.

But the cancer cells are alkaline due to exporting lactate and hydrogen ions. So, if anything can drop the intracellular pH, those cancer cells, because they’re deranged, should actually disappear by themselves.

And one of Peat’s suggestions at the time was, ‘Why don’t you use the drug acetazolamide?’ which as a carbonic anhydrase inhibitor, increases carbon dioxide. Carbon dioxide is acidic, and then that should allow cancer cells to commit apoptosis.

There are some studies in vitro and in vivo showing that acetazolamide may work, but it didn’t really cure the tumors. It was a slower growth, partial regression, but it showed that the idea was on the right track.

So, I said, ‘Let’s find something that’s much more acidic than carbon dioxide.’ And that is this 2,6-dihydroxybenzoic acid, which is just one extra hydroxyl group on top of aspirin. Salicylic acid, really, which is 2-hydroxybenzoic acid. And then this thing is about 10 times more potent than aspirin.”

That said, consider adding aspirin into your health routine. But don’t just select any aspirin available — opt for immediate-release formulations instead of the coated extended-release varieties. Pay attention to the ingredients as well. Ideally, corn starch should be the only additive listed.

After doing my own research, I identified a product meeting these criteria. The appropriate dosage ranges from 82 mg to 325 mg daily, taken with your largest meal, depending on your individual needs.

In the context of cancer prevention, the dosage and duration of aspirin are crucial factors. Low doses (75 to 300 mg/day) have been shown to be as effective as higher doses in reducing colorectal cancer-related mortality,¹⁷ which means there’s no need to take large amounts to gain the benefits.

Consistency and long-term use seem to be key, however. Studies indicate that aspirin’s benefits increase with duration, with significant reductions in cancer risk observed after five to 7.5 years of consistent use.¹⁸

I personally take 111 mg daily using Health Natura’s USP grade 60 gram aspirin powder, which costs less than $20. This 99% pure USP aspirin powder appeals to me due to its prometabolic, antilipolytic, anti-inflammatory, anticortisol and anti-estrogen effects. Its safety profile is also well-established.

• ^1, 2 American Cancer Society, “Key Statistics for Prostate Cancer”
• ³ National Cancer Institute, “Cancer Stat Facts: Prostate Cancer”
• ⁴ Nat Genet. 2024 Sep 9. doi: 10.1038/s41588-024-01893-6, Abstract
• ⁵ Britannica, “Androgen”
• ⁶ Cleveland Clinic, “Androgens”
• ⁷ MedlinePlus, “AR Gene”
• ⁸ Nat Genet. 2024 Sep 9. doi: 10.1038/s41588-024-01893-6, Main
• ⁹ Nat Genet. 2024 Sep 9. doi: 10.1038/s41588-024-01893-6, Ethical Statement
• ¹⁰ Nat Genet. 2024 Sep 9. doi: 10.1038/s41588-024-01893-6, Functional CRISPR Screen Reveals NSD2 as an AR Coactivator
• ¹¹ Michigan Medicine, September 9, 2024
• ¹² American Journal of Clinical Nutrition 2012 Oct; 96(4): 855–863, Abstract
• ¹³ Nutrients. 2023 Sep; 15(18): 4036, Abstract
• ¹⁴ Scientific Reports, volume 13, Article number: 22144 (2023), Abstract
• ¹⁵ European Journal of Clinical Nutrition, volume 77, pages 1160–1166 (2023), Abstract
• ¹⁶ World Wildlife Fund, Assessing Plastic Ingestion from Nature to People, page 7
• ^17, 18 Cureus. 2024 Feb; 16(2): e54658, Review

• Ozempic and similar weight loss drugs have been linked to 162 deaths in the U.S., with adverse reactions increasing by 40% in six months as usage expands
• These medications are associated with serious side effects, including pancreatitis, bowel obstruction and stomach paralysis, with 80% to 90% of users experiencing at least one adverse event
• Studies have found a significant link between semaglutide (the active ingredient in Ozempic) and suicidal ideation, particularly in patients also taking antidepressants or antianxiety medications
• Emerging reports indicate severe kidney problems in some patients using these weight loss drugs
• Akkermansia, a beneficial gut bacteria, is a natural alternative to stimulate GLP-1 production, offering similar benefits without the risks associated with drugs like Ozempic

(Mercola)—Glucagon-like peptide-1 (GLP-1) receptor agonists, including semaglutide — the active ingredient in Ozempic and Wegovy — have taken the world by storm. Originally developed for Type 2 diabetes, these drugs’ weight loss properties quickly caught the attention of researchers and the public alike.

Their effectiveness in shedding pounds has led to a global shortage, with an estimated 20 million people using them annually.¹ But as with any quick fix, there’s often a catch. According to data from the U.S. Food and Drug Administration’s (FDA) Adverse Event Reporting System (FAERS), these medications have been linked to 162 deaths in the U.S.²

The Daily Mail reports that fatalities mentioning weight loss drugs have increased by 40% in just six months, jumping from 117 to 162 reported deaths.³ This sharp rise coincides with the expanding use of these medications, as more formulations hit the market and off-label prescriptions become commonplace.

However, your risk doesn’t disappear simply because you’re using these drugs as directed. The FAERS data show that adverse reactions occur in patients using these medications for their approved purposes, whether for diabetes management or weight loss.

Ozempic-Related Deaths and ‘Serious’ Reactions on the Rise

The FAERS database reveals a disturbing trend in adverse reactions to weight loss drugs containing semaglutide and tirzepatide (used in Mounjaro and Zepbound). Since 2018, there have been 62,000 reported reactions to these medications in the U.S.⁴

What’s particularly alarming is that 46,000 of these reports — nearly three-quarters of the total — occurred after 2022. This coincides with the increased availability and marketing of these drugs. Of the 162 reported deaths, 94 were linked to semaglutide-based drugs, while 68 were associated with tirzepatide medications. It’s worth noting that in 2023, tirzepatide was linked to nearly twice as many adverse reactions as semaglutide.⁵

The FAERS system has recorded 10,000 “serious” reactions to these weight loss drugs, defined as events resulting in hospitalization or life-threatening conditions. These aren’t just minor inconveniences; they’re significant medical events that could have long-lasting impacts on your health.

For instance, Daily Mail reports a case of a 30-year-old man on Ozempic who was hospitalized with pancreatitis, an inflammation of the pancreas that causes severe abdominal pain. In another case, a 49-year-old woman taking Ozempic experienced mania and a dangerous surge in blood pressure, requiring hospitalization.⁶

While 1.7% of Americans — approximately 5.6 million people — were prescribed weight loss drugs in 2023, recent surveys suggest that number has grown to about 6% of U.S. adults, or 15.5 million people.⁷ This rapid increase in usage means more individuals are exposed to the serious side effects.

Ozempic Linked to Suicidal Ideation

A comprehensive study analyzing the World Health Organization’s database of adverse drug reactions uncovered more troubling findings about Ozempic.⁸ The research, which looked at over 36.1 million reports, found a significant link between semaglutide and suicidal ideation.

Out of 30,527 total reports for semaglutide, 107 cases of suicidal or self-injurious reactions were identified, and the association remained significant even after accounting for other factors. The research revealed a 45% increased risk of suicidal ideation in patients taking semaglutide compared to other medications.⁹

Further, people taking antidepressants or antianxiety medications alongside semaglutide were at an even higher risk of reporting suicidal thoughts — a 150% to 300% increase in suicidal ideation was found among this group.¹⁰

A study in Frontiers in Psychiatry revealed insights into semaglutide’s impact on your emotional state and psychological well-being.¹¹ The drug’s main component targets GLP-1 receptors, which are present not just in your digestive tract but also in critical brain areas. These regions, such as the lateral septum and hypothalamus, are essential for managing emotions, reward systems and appetite control.

Semaglutide’s interaction with these receptors modifies the functioning of neural pathways involved in these processes. Particularly noteworthy is its influence on dopamine, a neurotransmitter closely associated with mood regulation and reward perception.

Research indicates that stimulating GLP-1 receptors may enhance dopamine transporter expression, leading to decreased free dopamine levels in specific brain regions. This shift in dopamine signaling might lead to alterations in your mood, motivation levels, and even how you experience pleasure.

Up to 90% of Ozempic Users Experience an Adverse Event

The most common side effects linked to Ozempic and similar drugs are gastrointestinal, including nausea, diarrhea and vomiting. In clinical trials, a staggering 80% to 90% of participants experienced at least one adverse event.¹² Though most were mild to moderate, they led some people to discontinue the medication.

Further, these drugs are intended for long-term use — stopping them often results in weight regain — further increasing the risk of side effects over time. While nausea and diarrhea might seem manageable, more severe health risks, including pancreatitis, are a real concern. A study of 16 million patients found that those taking liraglutide or semaglutide had over nine times the risk of developing pancreatitis compared to those on other weight loss medications.¹³

The same study showed a four-fold increase in the risk of bowel obstruction and nearly four times the risk of gastroparesis (stomach paralysis). Gallbladder issues are another significant concern. Clinical trials revealed higher rates of gallstones and cholecystitis (gallbladder inflammation) in people taking these drugs.¹⁴

While rare, some patients required surgery for these complications. It’s also worth noting that these medications increase heart rate.¹⁵ There’s also the potential for aspiration during anesthesia. These drugs slow down stomach emptying, which means you may still have food in your stomach even after fasting for the recommended time before surgery. This increases the risk of aspiration pneumonia, a serious complication.

The FDA has also warned that Ozempic causes an intestinal blockage called ileus,¹⁶ which can lead to life-threatening complications if not treated promptly.

Another Ozempic Dark Side: Kidney Damage

Troubling reports of severe kidney problems due to Ozempic are also emerging. Research published in the Clinical Kidney Journal reported two patients experienced acute interstitial nephritis (AIN), a serious kidney inflammation, after starting semaglutide.¹⁷

One case even involved focal segmental glomerulosclerosis (FSGS), a type of kidney scarring. These findings suggest these drugs pose significant risks to your kidney health, especially if you have pre-existing kidney issues. The first case involved a 68-year-old woman with chronic kidney disease who started semaglutide for weight loss.

Within weeks, she developed severe nausea and vomiting, leading to a dramatic increase in her creatinine levels — a key indicator of kidney function. Even after stopping the medication, her kidney function worsened upon restarting it. A biopsy confirmed acute interstitial nephritis, likely triggered by semaglutide.¹⁸

The second case was even more alarming. A 49-year-old woman with no prior kidney issues developed severe swelling and protein in her urine after three months on semaglutide. Her kidney biopsy revealed not only AIN but also FSGS, a condition that can lead to kidney failure.

The study authors suggest that risk factors for these complications may include chronic kidney disease, advanced age, obesity and concurrent use of other medications that can affect the kidneys. A review of the FDA’s adverse event reporting system revealed 2,375 kidney-related events associated with GLP-1 drugs between 2010 and 2022.¹⁹

Acute kidney injury was the most common, accounting for nearly 59% of reports. Other reported issues included high blood pressure, electrolyte imbalances and, in rare cases, severe protein loss in the urine.

Akkermansia: A Natural Ozempic Alternative

Sustainable weight loss involves more than just a quick fix. It requires a holistic approach that considers your overall health, including your mental well-being. As tempting as these drugs might seem, especially with their popularity on social media, it’s crucial to make decisions based on scientific evidence rather than anecdotal reports or trends. Your health is too important to gamble with unproven or potentially dangerous solutions.

In my interview with Dr. Colleen Cutcliffe, a molecular biology scientist and the CEO and co-founder of Pendulum, a company that creates microbiome products, she explained that, instead of using Ozempic, you can naturally elevate your GLP-1 levels by increasing the presence of the beneficial bacteria Akkermansia in your gut:

“What happens in your body naturally, if you’ve got all the right microbes, is that you eat a meal, your microbiome metabolizes that food and generates postbiotics [excretions from beneficial bacteria] like butyrate [and] a protein called P9. Some of these postbiotics then signal your body to produce GLP-1.

All that signaling is happening from the microbiome directly to the L cells. And so you eat a meal, your microbiome digests them, these postbiotics get created and tell your L cells, ‘Hey, go produce GLP-1,’ and then you get a spike in GLP-1 in your body.

GLP-1 stimulates your body too. It says, ‘We’ve got to metabolize the sugar in the bloodstream, release insulin.’ It also signals to your brain, ‘We just ate, we’re full, we don’t need to eat again.’ After a period of time, GLP-1 goes down — until the next time you eat a meal. Then it spikes again.

So that’s the natural way of things. There are only two strains that have been published, to date, that have been shown to be able to stimulate L cells to produce GLP-1, and one of them is Akkermansia. It actually secretes three different [postbiotics] that stimulate L cells to produce GLP-1.

So, what’s been found is that if you are low or missing Akkermansia, your body is not naturally producing as much GLP-1 as it’s supposed to be. By giving people back Akkermansia, you can now have these physiological benefits of reducing A1C and lowering blood glucose spikes.

To be clear, the natural GLP-1 you produce is different from the drug. The drug is a mimic. It’s an analog. It looks like GLP-1. It gets injected into the bloodstream directly, which means that rather than the natural spike after you eat [followed by a decline], the [drug] is keeping those levels really high all the time.

So, this signaling of ‘we got to metabolize sugar in the blood and we’re full, we just ate’ is going on constantly. That’s why people experience these incredible, amazing overnight effects because that’s how those drugs are working. But if you actually have the right microbes, you can generate your body’s natural GLP-1 and get back into this natural cycle.”

Many People Are Lacking Akkermansia

Research published in Nature Microbiology found that Akkermansia increased thermogenesis and GLP-1 secretion in mice fed a high-fat diet.²⁰ While Akkermansia plays a vital role in maintaining intestinal health, many individuals have insufficient levels due to compromised mitochondrial function and oxygen leakage in the gut.

One of Akkermansia’s primary functions is the production of short-chain fatty acids (SCFAs), including butyrate. These fatty acids serve as fuel for your colonocytes, which in turn produce mucin, a gel-like protective substance that coats your gut lining.

SCFAs also help remove oxygen from your colon, creating an environment where beneficial bacteria can flourish. Mucin acts as a barrier, shielding intestinal cells from damage, harmful microorganisms and digestive irritants.

Additionally, mucin enhances your immune system. It contains antibodies and antimicrobial peptides that help fight infections. Mucin also functions as a trap for potential pathogens, facilitating their elimination through the digestive process. Akkermansia is so beneficial that it should, ideally, constitute about 10% of your gut microbiome.

Make Sure Live Akkermansia Probiotics Reach Your Colon

When selecting Akkermansia probiotics, opt for products with bacterial counts in the billions rather than millions. Generally, a higher bacterial count is beneficial, but there’s an important caveat: the delivery method is crucial.

Look for probiotics in delayed-release capsules. This feature is essential because it ensures the beneficial bacteria have a higher likelihood of reaching your colon alive. Without this protective mechanism, most of the bacteria may not survive the journey through your digestive system.

Akkermansia are very sensitive to oxygen. This makes their journey through your digestive system very challenging. These beneficial microbes thrive in an oxygen-free environment, and even a brief exposure to oxygen can be fatal for them. This trait makes the delivery method of Akkermansia supplements crucial to their effectiveness.

In fact, a lower-dose probiotic (in the hundreds of thousands of bacteria) that successfully reaches your colon can be more effective than a high-dose product (with hundreds of billions of bacteria) that doesn’t make it to its intended destination. Remember, when it comes to probiotics, successful delivery to the colon is just as important as the initial dosage.

Understanding this helps you choose the most effective supplement. You want to nurture your gut microbiome with live, active Akkermansia, as dead or inactive ones won’t do you as much good as they don’t reproduce.

If you want to use Akkermansia supplements, look for ones with advanced, dual-timed release capsules or microencapsulation. These technologies keep Akkermansia dormant and protected until it reaches your colon, usually in two to four hours.

To maximize its effectiveness, take it on an empty stomach, ideally first thing in the morning after an overnight fast. Wait at least one to two hours before eating to reduce transit time, allowing the bacteria to reach your colon faster — usually within two hours. This will greatly increase the number of live bacteria that make it to your colon.

Avoid taking probiotics with food, as this can extend your transit time to over eight hours, likely killing the bacteria long before they reach your colon. Being mindful of when and how you take your Akkermansia probiotic will maximize the benefits of this powerful probiotic.

• ^1, 8, 9 JAMA Netw Open. 2024 Aug 20;7(8):e2423385
• ^{2, 3, 4, 5, 6, 7} Daily Mail September 8, 2024
• ¹⁰ ZeroHedge August 21, 2024
• ¹¹ Front Psychiatry. 2023 Aug 29;14:1238353
• ^{12, 13, 14, 15} Obes Pillars. 2024 Aug 31;12:100127
• ¹⁶ U.S. FDA, Drug Safety-related Labeling Changes, Ozempic September 22, 2023
• ^17, 18, 19 Clin Kidney J. 2024 Aug 13;17(9):sfae250
• ²⁰ Nature Microbiology volume 6, pages 563–573 (2021)

• Ozempic and similar weight loss drugs have been linked to 162 deaths in the U.S., with adverse reactions increasing by 40% in six months as usage expands
• These medications are associated with serious side effects, including pancreatitis, bowel obstruction and stomach paralysis, with 80% to 90% of users experiencing at least one adverse event
• Studies have found a significant link between semaglutide (the active ingredient in Ozempic) and suicidal ideation, particularly in patients also taking antidepressants or antianxiety medications
• Emerging reports indicate severe kidney problems in some patients using these weight loss drugs
• Akkermansia, a beneficial gut bacteria, is a natural alternative to stimulate GLP-1 production, offering similar benefits without the risks associated with drugs like Ozempic

(Mercola)—Glucagon-like peptide-1 (GLP-1) receptor agonists, including semaglutide — the active ingredient in Ozempic and Wegovy — have taken the world by storm. Originally developed for Type 2 diabetes, these drugs’ weight loss properties quickly caught the attention of researchers and the public alike.

Their effectiveness in shedding pounds has led to a global shortage, with an estimated 20 million people using them annually.¹ But as with any quick fix, there’s often a catch. According to data from the U.S. Food and Drug Administration’s (FDA) Adverse Event Reporting System (FAERS), these medications have been linked to 162 deaths in the U.S.²

The Daily Mail reports that fatalities mentioning weight loss drugs have increased by 40% in just six months, jumping from 117 to 162 reported deaths.³ This sharp rise coincides with the expanding use of these medications, as more formulations hit the market and off-label prescriptions become commonplace.

However, your risk doesn’t disappear simply because you’re using these drugs as directed. The FAERS data show that adverse reactions occur in patients using these medications for their approved purposes, whether for diabetes management or weight loss.

Ozempic-Related Deaths and ‘Serious’ Reactions on the Rise

The FAERS database reveals a disturbing trend in adverse reactions to weight loss drugs containing semaglutide and tirzepatide (used in Mounjaro and Zepbound). Since 2018, there have been 62,000 reported reactions to these medications in the U.S.⁴

What’s particularly alarming is that 46,000 of these reports — nearly three-quarters of the total — occurred after 2022. This coincides with the increased availability and marketing of these drugs. Of the 162 reported deaths, 94 were linked to semaglutide-based drugs, while 68 were associated with tirzepatide medications. It’s worth noting that in 2023, tirzepatide was linked to nearly twice as many adverse reactions as semaglutide.⁵

The FAERS system has recorded 10,000 “serious” reactions to these weight loss drugs, defined as events resulting in hospitalization or life-threatening conditions. These aren’t just minor inconveniences; they’re significant medical events that could have long-lasting impacts on your health.

For instance, Daily Mail reports a case of a 30-year-old man on Ozempic who was hospitalized with pancreatitis, an inflammation of the pancreas that causes severe abdominal pain. In another case, a 49-year-old woman taking Ozempic experienced mania and a dangerous surge in blood pressure, requiring hospitalization.⁶

While 1.7% of Americans — approximately 5.6 million people — were prescribed weight loss drugs in 2023, recent surveys suggest that number has grown to about 6% of U.S. adults, or 15.5 million people.⁷ This rapid increase in usage means more individuals are exposed to the serious side effects.

Ozempic Linked to Suicidal Ideation

A comprehensive study analyzing the World Health Organization’s database of adverse drug reactions uncovered more troubling findings about Ozempic.⁸ The research, which looked at over 36.1 million reports, found a significant link between semaglutide and suicidal ideation.

Out of 30,527 total reports for semaglutide, 107 cases of suicidal or self-injurious reactions were identified, and the association remained significant even after accounting for other factors. The research revealed a 45% increased risk of suicidal ideation in patients taking semaglutide compared to other medications.⁹

Further, people taking antidepressants or antianxiety medications alongside semaglutide were at an even higher risk of reporting suicidal thoughts — a 150% to 300% increase in suicidal ideation was found among this group.¹⁰

A study in Frontiers in Psychiatry revealed insights into semaglutide’s impact on your emotional state and psychological well-being.¹¹ The drug’s main component targets GLP-1 receptors, which are present not just in your digestive tract but also in critical brain areas. These regions, such as the lateral septum and hypothalamus, are essential for managing emotions, reward systems and appetite control.

Semaglutide’s interaction with these receptors modifies the functioning of neural pathways involved in these processes. Particularly noteworthy is its influence on dopamine, a neurotransmitter closely associated with mood regulation and reward perception.

Research indicates that stimulating GLP-1 receptors may enhance dopamine transporter expression, leading to decreased free dopamine levels in specific brain regions. This shift in dopamine signaling might lead to alterations in your mood, motivation levels, and even how you experience pleasure.

Up to 90% of Ozempic Users Experience an Adverse Event

The most common side effects linked to Ozempic and similar drugs are gastrointestinal, including nausea, diarrhea and vomiting. In clinical trials, a staggering 80% to 90% of participants experienced at least one adverse event.¹² Though most were mild to moderate, they led some people to discontinue the medication.

Further, these drugs are intended for long-term use — stopping them often results in weight regain — further increasing the risk of side effects over time. While nausea and diarrhea might seem manageable, more severe health risks, including pancreatitis, are a real concern. A study of 16 million patients found that those taking liraglutide or semaglutide had over nine times the risk of developing pancreatitis compared to those on other weight loss medications.¹³

The same study showed a four-fold increase in the risk of bowel obstruction and nearly four times the risk of gastroparesis (stomach paralysis). Gallbladder issues are another significant concern. Clinical trials revealed higher rates of gallstones and cholecystitis (gallbladder inflammation) in people taking these drugs.¹⁴

While rare, some patients required surgery for these complications. It’s also worth noting that these medications increase heart rate.¹⁵ There’s also the potential for aspiration during anesthesia. These drugs slow down stomach emptying, which means you may still have food in your stomach even after fasting for the recommended time before surgery. This increases the risk of aspiration pneumonia, a serious complication.

The FDA has also warned that Ozempic causes an intestinal blockage called ileus,¹⁶ which can lead to life-threatening complications if not treated promptly.

Another Ozempic Dark Side: Kidney Damage

Troubling reports of severe kidney problems due to Ozempic are also emerging. Research published in the Clinical Kidney Journal reported two patients experienced acute interstitial nephritis (AIN), a serious kidney inflammation, after starting semaglutide.¹⁷

One case even involved focal segmental glomerulosclerosis (FSGS), a type of kidney scarring. These findings suggest these drugs pose significant risks to your kidney health, especially if you have pre-existing kidney issues. The first case involved a 68-year-old woman with chronic kidney disease who started semaglutide for weight loss.

Within weeks, she developed severe nausea and vomiting, leading to a dramatic increase in her creatinine levels — a key indicator of kidney function. Even after stopping the medication, her kidney function worsened upon restarting it. A biopsy confirmed acute interstitial nephritis, likely triggered by semaglutide.¹⁸

The second case was even more alarming. A 49-year-old woman with no prior kidney issues developed severe swelling and protein in her urine after three months on semaglutide. Her kidney biopsy revealed not only AIN but also FSGS, a condition that can lead to kidney failure.

The study authors suggest that risk factors for these complications may include chronic kidney disease, advanced age, obesity and concurrent use of other medications that can affect the kidneys. A review of the FDA’s adverse event reporting system revealed 2,375 kidney-related events associated with GLP-1 drugs between 2010 and 2022.¹⁹

Acute kidney injury was the most common, accounting for nearly 59% of reports. Other reported issues included high blood pressure, electrolyte imbalances and, in rare cases, severe protein loss in the urine.

Akkermansia: A Natural Ozempic Alternative

Sustainable weight loss involves more than just a quick fix. It requires a holistic approach that considers your overall health, including your mental well-being. As tempting as these drugs might seem, especially with their popularity on social media, it’s crucial to make decisions based on scientific evidence rather than anecdotal reports or trends. Your health is too important to gamble with unproven or potentially dangerous solutions.

In my interview with Dr. Colleen Cutcliffe, a molecular biology scientist and the CEO and co-founder of Pendulum, a company that creates microbiome products, she explained that, instead of using Ozempic, you can naturally elevate your GLP-1 levels by increasing the presence of the beneficial bacteria Akkermansia in your gut:

“What happens in your body naturally, if you’ve got all the right microbes, is that you eat a meal, your microbiome metabolizes that food and generates postbiotics [excretions from beneficial bacteria] like butyrate [and] a protein called P9. Some of these postbiotics then signal your body to produce GLP-1.

All that signaling is happening from the microbiome directly to the L cells. And so you eat a meal, your microbiome digests them, these postbiotics get created and tell your L cells, ‘Hey, go produce GLP-1,’ and then you get a spike in GLP-1 in your body.

GLP-1 stimulates your body too. It says, ‘We’ve got to metabolize the sugar in the bloodstream, release insulin.’ It also signals to your brain, ‘We just ate, we’re full, we don’t need to eat again.’ After a period of time, GLP-1 goes down — until the next time you eat a meal. Then it spikes again.

So that’s the natural way of things. There are only two strains that have been published, to date, that have been shown to be able to stimulate L cells to produce GLP-1, and one of them is Akkermansia. It actually secretes three different [postbiotics] that stimulate L cells to produce GLP-1.

So, what’s been found is that if you are low or missing Akkermansia, your body is not naturally producing as much GLP-1 as it’s supposed to be. By giving people back Akkermansia, you can now have these physiological benefits of reducing A1C and lowering blood glucose spikes.

To be clear, the natural GLP-1 you produce is different from the drug. The drug is a mimic. It’s an analog. It looks like GLP-1. It gets injected into the bloodstream directly, which means that rather than the natural spike after you eat [followed by a decline], the [drug] is keeping those levels really high all the time.

So, this signaling of ‘we got to metabolize sugar in the blood and we’re full, we just ate’ is going on constantly. That’s why people experience these incredible, amazing overnight effects because that’s how those drugs are working. But if you actually have the right microbes, you can generate your body’s natural GLP-1 and get back into this natural cycle.”

Many People Are Lacking Akkermansia

Research published in Nature Microbiology found that Akkermansia increased thermogenesis and GLP-1 secretion in mice fed a high-fat diet.²⁰ While Akkermansia plays a vital role in maintaining intestinal health, many individuals have insufficient levels due to compromised mitochondrial function and oxygen leakage in the gut.

One of Akkermansia’s primary functions is the production of short-chain fatty acids (SCFAs), including butyrate. These fatty acids serve as fuel for your colonocytes, which in turn produce mucin, a gel-like protective substance that coats your gut lining.

SCFAs also help remove oxygen from your colon, creating an environment where beneficial bacteria can flourish. Mucin acts as a barrier, shielding intestinal cells from damage, harmful microorganisms and digestive irritants.

Additionally, mucin enhances your immune system. It contains antibodies and antimicrobial peptides that help fight infections. Mucin also functions as a trap for potential pathogens, facilitating their elimination through the digestive process. Akkermansia is so beneficial that it should, ideally, constitute about 10% of your gut microbiome.

Make Sure Live Akkermansia Probiotics Reach Your Colon

When selecting Akkermansia probiotics, opt for products with bacterial counts in the billions rather than millions. Generally, a higher bacterial count is beneficial, but there’s an important caveat: the delivery method is crucial.

Look for probiotics in delayed-release capsules. This feature is essential because it ensures the beneficial bacteria have a higher likelihood of reaching your colon alive. Without this protective mechanism, most of the bacteria may not survive the journey through your digestive system.

Akkermansia are very sensitive to oxygen. This makes their journey through your digestive system very challenging. These beneficial microbes thrive in an oxygen-free environment, and even a brief exposure to oxygen can be fatal for them. This trait makes the delivery method of Akkermansia supplements crucial to their effectiveness.

In fact, a lower-dose probiotic (in the hundreds of thousands of bacteria) that successfully reaches your colon can be more effective than a high-dose product (with hundreds of billions of bacteria) that doesn’t make it to its intended destination. Remember, when it comes to probiotics, successful delivery to the colon is just as important as the initial dosage.

Understanding this helps you choose the most effective supplement. You want to nurture your gut microbiome with live, active Akkermansia, as dead or inactive ones won’t do you as much good as they don’t reproduce.

If you want to use Akkermansia supplements, look for ones with advanced, dual-timed release capsules or microencapsulation. These technologies keep Akkermansia dormant and protected until it reaches your colon, usually in two to four hours.

To maximize its effectiveness, take it on an empty stomach, ideally first thing in the morning after an overnight fast. Wait at least one to two hours before eating to reduce transit time, allowing the bacteria to reach your colon faster — usually within two hours. This will greatly increase the number of live bacteria that make it to your colon.

Avoid taking probiotics with food, as this can extend your transit time to over eight hours, likely killing the bacteria long before they reach your colon. Being mindful of when and how you take your Akkermansia probiotic will maximize the benefits of this powerful probiotic.

• ^1, 8, 9 JAMA Netw Open. 2024 Aug 20;7(8):e2423385
• ^{2, 3, 4, 5, 6, 7} Daily Mail September 8, 2024
• ¹⁰ ZeroHedge August 21, 2024
• ¹¹ Front Psychiatry. 2023 Aug 29;14:1238353
• ^{12, 13, 14, 15} Obes Pillars. 2024 Aug 31;12:100127
• ¹⁶ U.S. FDA, Drug Safety-related Labeling Changes, Ozempic September 22, 2023
• ^17, 18, 19 Clin Kidney J. 2024 Aug 13;17(9):sfae250
• ²⁰ Nature Microbiology volume 6, pages 563–573 (2021)

• Ozempic and similar weight loss drugs have been linked to 162 deaths in the U.S., with adverse reactions increasing by 40% in six months as usage expands
• These medications are associated with serious side effects, including pancreatitis, bowel obstruction and stomach paralysis, with 80% to 90% of users experiencing at least one adverse event
• Studies have found a significant link between semaglutide (the active ingredient in Ozempic) and suicidal ideation, particularly in patients also taking antidepressants or antianxiety medications
• Emerging reports indicate severe kidney problems in some patients using these weight loss drugs
• Akkermansia, a beneficial gut bacteria, is a natural alternative to stimulate GLP-1 production, offering similar benefits without the risks associated with drugs like Ozempic

(Mercola)—Glucagon-like peptide-1 (GLP-1) receptor agonists, including semaglutide — the active ingredient in Ozempic and Wegovy — have taken the world by storm. Originally developed for Type 2 diabetes, these drugs’ weight loss properties quickly caught the attention of researchers and the public alike.

Their effectiveness in shedding pounds has led to a global shortage, with an estimated 20 million people using them annually.¹ But as with any quick fix, there’s often a catch. According to data from the U.S. Food and Drug Administration’s (FDA) Adverse Event Reporting System (FAERS), these medications have been linked to 162 deaths in the U.S.²

The Daily Mail reports that fatalities mentioning weight loss drugs have increased by 40% in just six months, jumping from 117 to 162 reported deaths.³ This sharp rise coincides with the expanding use of these medications, as more formulations hit the market and off-label prescriptions become commonplace.

However, your risk doesn’t disappear simply because you’re using these drugs as directed. The FAERS data show that adverse reactions occur in patients using these medications for their approved purposes, whether for diabetes management or weight loss.

Ozempic-Related Deaths and ‘Serious’ Reactions on the Rise

The FAERS database reveals a disturbing trend in adverse reactions to weight loss drugs containing semaglutide and tirzepatide (used in Mounjaro and Zepbound). Since 2018, there have been 62,000 reported reactions to these medications in the U.S.⁴

What’s particularly alarming is that 46,000 of these reports — nearly three-quarters of the total — occurred after 2022. This coincides with the increased availability and marketing of these drugs. Of the 162 reported deaths, 94 were linked to semaglutide-based drugs, while 68 were associated with tirzepatide medications. It’s worth noting that in 2023, tirzepatide was linked to nearly twice as many adverse reactions as semaglutide.⁵

The FAERS system has recorded 10,000 “serious” reactions to these weight loss drugs, defined as events resulting in hospitalization or life-threatening conditions. These aren’t just minor inconveniences; they’re significant medical events that could have long-lasting impacts on your health.

For instance, Daily Mail reports a case of a 30-year-old man on Ozempic who was hospitalized with pancreatitis, an inflammation of the pancreas that causes severe abdominal pain. In another case, a 49-year-old woman taking Ozempic experienced mania and a dangerous surge in blood pressure, requiring hospitalization.⁶

While 1.7% of Americans — approximately 5.6 million people — were prescribed weight loss drugs in 2023, recent surveys suggest that number has grown to about 6% of U.S. adults, or 15.5 million people.⁷ This rapid increase in usage means more individuals are exposed to the serious side effects.

Ozempic Linked to Suicidal Ideation

A comprehensive study analyzing the World Health Organization’s database of adverse drug reactions uncovered more troubling findings about Ozempic.⁸ The research, which looked at over 36.1 million reports, found a significant link between semaglutide and suicidal ideation.

Out of 30,527 total reports for semaglutide, 107 cases of suicidal or self-injurious reactions were identified, and the association remained significant even after accounting for other factors. The research revealed a 45% increased risk of suicidal ideation in patients taking semaglutide compared to other medications.⁹

Further, people taking antidepressants or antianxiety medications alongside semaglutide were at an even higher risk of reporting suicidal thoughts — a 150% to 300% increase in suicidal ideation was found among this group.¹⁰

A study in Frontiers in Psychiatry revealed insights into semaglutide’s impact on your emotional state and psychological well-being.¹¹ The drug’s main component targets GLP-1 receptors, which are present not just in your digestive tract but also in critical brain areas. These regions, such as the lateral septum and hypothalamus, are essential for managing emotions, reward systems and appetite control.

Semaglutide’s interaction with these receptors modifies the functioning of neural pathways involved in these processes. Particularly noteworthy is its influence on dopamine, a neurotransmitter closely associated with mood regulation and reward perception.

Research indicates that stimulating GLP-1 receptors may enhance dopamine transporter expression, leading to decreased free dopamine levels in specific brain regions. This shift in dopamine signaling might lead to alterations in your mood, motivation levels, and even how you experience pleasure.

Up to 90% of Ozempic Users Experience an Adverse Event

The most common side effects linked to Ozempic and similar drugs are gastrointestinal, including nausea, diarrhea and vomiting. In clinical trials, a staggering 80% to 90% of participants experienced at least one adverse event.¹² Though most were mild to moderate, they led some people to discontinue the medication.

Further, these drugs are intended for long-term use — stopping them often results in weight regain — further increasing the risk of side effects over time. While nausea and diarrhea might seem manageable, more severe health risks, including pancreatitis, are a real concern. A study of 16 million patients found that those taking liraglutide or semaglutide had over nine times the risk of developing pancreatitis compared to those on other weight loss medications.¹³

The same study showed a four-fold increase in the risk of bowel obstruction and nearly four times the risk of gastroparesis (stomach paralysis). Gallbladder issues are another significant concern. Clinical trials revealed higher rates of gallstones and cholecystitis (gallbladder inflammation) in people taking these drugs.¹⁴

While rare, some patients required surgery for these complications. It’s also worth noting that these medications increase heart rate.¹⁵ There’s also the potential for aspiration during anesthesia. These drugs slow down stomach emptying, which means you may still have food in your stomach even after fasting for the recommended time before surgery. This increases the risk of aspiration pneumonia, a serious complication.

The FDA has also warned that Ozempic causes an intestinal blockage called ileus,¹⁶ which can lead to life-threatening complications if not treated promptly.

Another Ozempic Dark Side: Kidney Damage

Troubling reports of severe kidney problems due to Ozempic are also emerging. Research published in the Clinical Kidney Journal reported two patients experienced acute interstitial nephritis (AIN), a serious kidney inflammation, after starting semaglutide.¹⁷

One case even involved focal segmental glomerulosclerosis (FSGS), a type of kidney scarring. These findings suggest these drugs pose significant risks to your kidney health, especially if you have pre-existing kidney issues. The first case involved a 68-year-old woman with chronic kidney disease who started semaglutide for weight loss.

Within weeks, she developed severe nausea and vomiting, leading to a dramatic increase in her creatinine levels — a key indicator of kidney function. Even after stopping the medication, her kidney function worsened upon restarting it. A biopsy confirmed acute interstitial nephritis, likely triggered by semaglutide.¹⁸

The second case was even more alarming. A 49-year-old woman with no prior kidney issues developed severe swelling and protein in her urine after three months on semaglutide. Her kidney biopsy revealed not only AIN but also FSGS, a condition that can lead to kidney failure.

The study authors suggest that risk factors for these complications may include chronic kidney disease, advanced age, obesity and concurrent use of other medications that can affect the kidneys. A review of the FDA’s adverse event reporting system revealed 2,375 kidney-related events associated with GLP-1 drugs between 2010 and 2022.¹⁹

Acute kidney injury was the most common, accounting for nearly 59% of reports. Other reported issues included high blood pressure, electrolyte imbalances and, in rare cases, severe protein loss in the urine.

Akkermansia: A Natural Ozempic Alternative

Sustainable weight loss involves more than just a quick fix. It requires a holistic approach that considers your overall health, including your mental well-being. As tempting as these drugs might seem, especially with their popularity on social media, it’s crucial to make decisions based on scientific evidence rather than anecdotal reports or trends. Your health is too important to gamble with unproven or potentially dangerous solutions.

In my interview with Dr. Colleen Cutcliffe, a molecular biology scientist and the CEO and co-founder of Pendulum, a company that creates microbiome products, she explained that, instead of using Ozempic, you can naturally elevate your GLP-1 levels by increasing the presence of the beneficial bacteria Akkermansia in your gut:

“What happens in your body naturally, if you’ve got all the right microbes, is that you eat a meal, your microbiome metabolizes that food and generates postbiotics [excretions from beneficial bacteria] like butyrate [and] a protein called P9. Some of these postbiotics then signal your body to produce GLP-1.

All that signaling is happening from the microbiome directly to the L cells. And so you eat a meal, your microbiome digests them, these postbiotics get created and tell your L cells, ‘Hey, go produce GLP-1,’ and then you get a spike in GLP-1 in your body.

GLP-1 stimulates your body too. It says, ‘We’ve got to metabolize the sugar in the bloodstream, release insulin.’ It also signals to your brain, ‘We just ate, we’re full, we don’t need to eat again.’ After a period of time, GLP-1 goes down — until the next time you eat a meal. Then it spikes again.

So that’s the natural way of things. There are only two strains that have been published, to date, that have been shown to be able to stimulate L cells to produce GLP-1, and one of them is Akkermansia. It actually secretes three different [postbiotics] that stimulate L cells to produce GLP-1.

So, what’s been found is that if you are low or missing Akkermansia, your body is not naturally producing as much GLP-1 as it’s supposed to be. By giving people back Akkermansia, you can now have these physiological benefits of reducing A1C and lowering blood glucose spikes.

To be clear, the natural GLP-1 you produce is different from the drug. The drug is a mimic. It’s an analog. It looks like GLP-1. It gets injected into the bloodstream directly, which means that rather than the natural spike after you eat [followed by a decline], the [drug] is keeping those levels really high all the time.

So, this signaling of ‘we got to metabolize sugar in the blood and we’re full, we just ate’ is going on constantly. That’s why people experience these incredible, amazing overnight effects because that’s how those drugs are working. But if you actually have the right microbes, you can generate your body’s natural GLP-1 and get back into this natural cycle.”

Many People Are Lacking Akkermansia

Research published in Nature Microbiology found that Akkermansia increased thermogenesis and GLP-1 secretion in mice fed a high-fat diet.²⁰ While Akkermansia plays a vital role in maintaining intestinal health, many individuals have insufficient levels due to compromised mitochondrial function and oxygen leakage in the gut.

One of Akkermansia’s primary functions is the production of short-chain fatty acids (SCFAs), including butyrate. These fatty acids serve as fuel for your colonocytes, which in turn produce mucin, a gel-like protective substance that coats your gut lining.

SCFAs also help remove oxygen from your colon, creating an environment where beneficial bacteria can flourish. Mucin acts as a barrier, shielding intestinal cells from damage, harmful microorganisms and digestive irritants.

Additionally, mucin enhances your immune system. It contains antibodies and antimicrobial peptides that help fight infections. Mucin also functions as a trap for potential pathogens, facilitating their elimination through the digestive process. Akkermansia is so beneficial that it should, ideally, constitute about 10% of your gut microbiome.

Make Sure Live Akkermansia Probiotics Reach Your Colon

When selecting Akkermansia probiotics, opt for products with bacterial counts in the billions rather than millions. Generally, a higher bacterial count is beneficial, but there’s an important caveat: the delivery method is crucial.

Look for probiotics in delayed-release capsules. This feature is essential because it ensures the beneficial bacteria have a higher likelihood of reaching your colon alive. Without this protective mechanism, most of the bacteria may not survive the journey through your digestive system.

Akkermansia are very sensitive to oxygen. This makes their journey through your digestive system very challenging. These beneficial microbes thrive in an oxygen-free environment, and even a brief exposure to oxygen can be fatal for them. This trait makes the delivery method of Akkermansia supplements crucial to their effectiveness.

In fact, a lower-dose probiotic (in the hundreds of thousands of bacteria) that successfully reaches your colon can be more effective than a high-dose product (with hundreds of billions of bacteria) that doesn’t make it to its intended destination. Remember, when it comes to probiotics, successful delivery to the colon is just as important as the initial dosage.

Understanding this helps you choose the most effective supplement. You want to nurture your gut microbiome with live, active Akkermansia, as dead or inactive ones won’t do you as much good as they don’t reproduce.

If you want to use Akkermansia supplements, look for ones with advanced, dual-timed release capsules or microencapsulation. These technologies keep Akkermansia dormant and protected until it reaches your colon, usually in two to four hours.

To maximize its effectiveness, take it on an empty stomach, ideally first thing in the morning after an overnight fast. Wait at least one to two hours before eating to reduce transit time, allowing the bacteria to reach your colon faster — usually within two hours. This will greatly increase the number of live bacteria that make it to your colon.

Avoid taking probiotics with food, as this can extend your transit time to over eight hours, likely killing the bacteria long before they reach your colon. Being mindful of when and how you take your Akkermansia probiotic will maximize the benefits of this powerful probiotic.

• ^1, 8, 9 JAMA Netw Open. 2024 Aug 20;7(8):e2423385
• ^{2, 3, 4, 5, 6, 7} Daily Mail September 8, 2024
• ¹⁰ ZeroHedge August 21, 2024
• ¹¹ Front Psychiatry. 2023 Aug 29;14:1238353
• ^{12, 13, 14, 15} Obes Pillars. 2024 Aug 31;12:100127
• ¹⁶ U.S. FDA, Drug Safety-related Labeling Changes, Ozempic September 22, 2023
• ^17, 18, 19 Clin Kidney J. 2024 Aug 13;17(9):sfae250
• ²⁰ Nature Microbiology volume 6, pages 563–573 (2021)

(Mercola)—I’ve long been fascinated by cholesterol’s role in our health, and research published over the last few years challenges what we’ve been told for decades. For example, a groundbreaking study of over 23,000 people reveals surprising, never-before considered findings about the impact of race and genetics on cholesterol and its links to heart disease.

Is Lower Cholesterol Really a Good Thing?

You’ve been told that high cholesterol is bad and low cholesterol is good. But what if I told you that low cholesterol could actually harm your heart health? This might sound counterintuitive, but recent research has uncovered some surprising truths about cholesterol’s role in our bodies.

Cholesterol is a crucial component of cell membranes and a precursor to many important hormones.¹ It’s not just a harmful substance to be eliminated, but a vital part of our biology. In fact, cholesterol plays a key role in brain function, hormone production, and even vitamin D synthesis.

For decades, the medical community has focused on lowering cholesterol levels to prevent heart disease. This approach was based on studies like the Framingham Heart Study, which linked high cholesterol to increased cardiovascular risk. As a result, millions of people have been prescribed statins and told to follow low-fat diets.

However, new research is challenging this simplistic view. The REGARDS (REasons for Geographic and Racial Differences in Stroke) study² published in the Journal of the American College of Cardiology examined data from 23,901 participants over a median follow-up of 10.7 years.

The researchers found that the relationship between HDL cholesterol and heart disease risk actually varied depending on race. Low levels of high-density lipoprotein (HDL) cholesterol — often called “good” cholesterol — were only associated with increased risk of coronary heart disease in White adults. Even more surprisingly, high levels of HDL cholesterol didn’t seem to protect against heart disease in either White or Black adults.

This revelation challenges decades of medical advice that has emphasized raising HDL cholesterol levels as a way to improve heart health. It also highlights the importance of considering racial differences in health research and treatment recommendations.

Another intriguing discovery is the “cholesterol paradox” observed in various health conditions.³ In some cases, individuals with low cholesterol levels actually had worse health outcomes than those with higher levels — a finding that flies in the face of long-held beliefs about cholesterol and health. As noted in one 2023 scientific review:

“On average, patients with a total cholesterol level of 232 mg/dl had a 25% higher survival rate than those with a total cholesterol level of 193 mg/dl who were suffering from heart failure. A total cholesterol level under 200 mg/dl is generally preferred.”⁴

These unexpected results raise important questions about how we assess cardiovascular risk and whether current treatment guidelines are appropriate for all populations. Clearly, the relationship between cholesterol and health isn’t nearly as straightforward as we once thought.

Complex Interplay of Factors Influence Cholesterol’s Effects

Aside from race, individual genetics also play a big part in how our bodies handle cholesterol. Some people naturally make more cholesterol, while others make less. This is why two people eating the same diet can have very different cholesterol levels.⁵

Inflammation and oxidative stress in our bodies can also impact how cholesterol affects our health. When there’s a lot of inflammation, cholesterol can act differently and cause problems that would not occur in someone that did not have the same level of inflammation. This is one reason why overall health is so important when thinking about cholesterol.⁶

This complex web of interactions makes it hard to predict exactly how cholesterol will affect each person’s health.⁷ Here’s a short list of factors that influence cholesterol’s effects:

1. Cellular energy production
2. Genetic factors
3. Inflammation and oxidative stress
4. Interaction with other metabolic processes

Understanding these relationships helps explain why low cholesterol isn’t always good and high cholesterol isn’t always bad.

Shifting Paradigms in Cholesterol Management

The revelations about cholesterol’s complex role in health are causing waves across the medical community and beyond. Importantly, these findings are prompting a reevaluation of cholesterol treatment guidelines that have been in place for decades.⁸

Healthcare providers are increasingly moving towards a more personalized approach to cholesterol management. Instead of relying solely on total cholesterol numbers, doctors are considering a wider range of factors including race, genetics, and overall health status when assessing cardiovascular risk.⁹

The pharmaceutical industry may need to adapt to new understandings of cholesterol’s role in health. As research reveals the complex relationship between cholesterol levels and heart disease risk across different populations, drug development and marketing strategies really ought to shift to reflect more personalized approaches to cardiovascular health management.¹⁰ Whether that will actually happen remains to be seen.

Public health messaging about cholesterol is also undergoing a transformation. The old mantra of “lower is always better” is being replaced with more nuanced advice. Dietary recommendations are shifting away from blanket low-fat guidelines to focus on overall diet quality and individual metabolic health.¹¹

These changes are empowering patients to take a more active role in their health management. With a better understanding of cholesterol’s complexities, you can make more informed decisions about your diet, lifestyle, and medical treatments.

Advanced lipid testing methods that provide more detailed information about cholesterol particle size and number are becoming increasingly important. These tests offer insights beyond standard lipid panels, allowing for more accurate cardiovascular risk assessment and targeted interventions.¹²

As our understanding of cholesterol continues to evolve, it’s clear that its impact extends far beyond individual health. It’s reshaping medical practice, influencing public health policy, and even affecting economic sectors.

To better understand the real-world implications of these findings, let’s look at some specific examples and case studies that illustrate the complexity of cholesterol management in different scenarios.

Real-World Scenarios Illustrate Complexity of Cholesterol Management

Consider the case of John, a 55-year-old White male with low HDL cholesterol levels. Traditional medical wisdom would have flagged him as high-risk for heart disease, and indeed, the REGARDS study^{13,14,15,16,17} confirmed that that low HDL cholesterol is associated with increased risk in White adults. So, for someone like John, a White male, the traditional wisdom about low HDL cholesterol increasing heart disease risk holds true.

In contrast, Maria, a 60-year-old Black woman with high HDL cholesterol, might have been considered at low risk for heart disease based on outdated guidelines. However, the new research suggests that high HDL levels aren’t necessarily protective for Black adults, prompting a reevaluation of Maria’s overall cardiovascular health beyond just her cholesterol numbers.

Another intriguing example is seen in highly trained, keto-adapted athletes. These individuals often display what appears to be paradoxically high cholesterol levels, yet they maintain excellent cardiovascular health.¹⁸ This phenomenon highlights the complex interplay between diet, physical activity, and cholesterol metabolism.

These scenarios underscore the need for a more nuanced and individualized approach to cholesterol management. They demonstrate that relying solely on standard cholesterol numbers can lead to misclassification of risk and inappropriate treatment decisions.

Given these complex scenarios, what can be done to optimize cholesterol management and improve health outcomes? The answer lies in a more holistic and personalized approach to health assessment and treatment.

Advanced Strategies for Optimizing Cholesterol Health

The takeaway is that improving cholesterol health goes beyond simply lowering your total cholesterol levels. A comprehensive approach that considers individual factors and overall metabolic health is key. Here are some strategies to promote optimal cholesterol balance. By embracing a more holistic strategy, you and your healthcare provider can work together to reduce your cardiovascular health risks.

• Personalized risk assessment — Healthcare providers should look beyond standard cholesterol numbers and consider factors like race, age, genetics, and lifestyle when evaluating cardiovascular risk.¹⁹
• Advanced lipid testing — This provides a more detailed picture of cholesterol levels than standard tests. These tests break down different types of LDL and HDL particles, giving you a clearer understanding of your individual heart disease risk.²⁰ Importantly, this detailed information helps identify individuals at risk even when their standard lipid panel appears normal.²¹
• Diet — Instead of focusing solely on lowering fat intake, focus on the quality of fats consumed. Incorporating foods rich in omega-3s, and saturated fats such as butter and coconut oil, will help you maintain a healthy cholesterol level while supporting your overall heart health.
• Exercise — Regular physical activity, especially a combination of aerobic exercise and strength training, helps improve lipid profiles and overall metabolic health.²²
• Targeted supplementation — For some individuals, targeted supplementation might be beneficial. For example, nutrients like omega-3s, niacin, and plant sterols have shown promise in supporting healthy cholesterol levels.²³

Sources and References

• ^{1, 3, 4, 5, 6, 7, 10, 11, 12, 14, 18, 21, 22, 23} Int. J. Res. Ayurveda Pharm. 14(2), 2023
• ^{2, 8, 9, 13, 19, 20} Journal of the American College of Cardiology Volume 80, Issue 22, November 29, 2022, Pages 2104-2115
• ¹⁵ NBC News, November 22, 2022
• ¹⁶ Healio, November 21, 2022
• ¹⁷ Medical News Today, November 22, 2022

• In my recent appearance on The Jimmy Dore Show, we discussed how mitochondrial dysfunction, caused by modern toxins, is at the root of many diseases. ATP production has decreased by up to 75% compared to a century ago
• I shared insights from my latest book, “Your Guide to Cellular Health: Unlocking the Science of Longevity and Joy,” including that seed oils, like soybean and corn oil, are major culprits in damaging cellular health, while natural sugars can be beneficial when used wisely
• Endocrine-disrupting chemicals and EMFs from devices like cellphones and Wi-Fi routers pose significant risks to mitochondrial function, necessitating practical steps to reduce exposure
• Powerful foundations and industry interests have shaped medical education and public health policies, often prioritizing pharmaceutical interventions over natural approaches
• Restoring cellular health involves eliminating toxins, adopting a whole foods diet, optimizing sun exposure and addressing gut health imbalances

(Mercola)—In my recent appearance on The Jimmy Dore Show, we explored a vital yet often overlooked aspect of human well-being — cellular health and the myriad of silent toxins eroding it. I shared insights from my latest book, “Your Guide to Cellular Health: Unlocking the Science of Longevity and Joy.”

This article reviews the most pivotal points from our extensive discussion, revealing the vital components that sustain health and the modern challenges that threaten them. As I shared with Dore, for 15 years I struggled with a mind-bending, unexplained rash that caused me to lose sleep at night because of unrelenting itching. All the physicians I consulted, some of the best out there, had no clue how to resolve it.

This personal battle led me to a groundbreaking realization: impaired mitochondrial function is at the heart of nearly every disease. Mitochondria, the powerhouses of your cells, produce adenosine triphosphate (ATP) — your body’s essential energy currency.

Everyone knows you can’t run a car without fuel. Similarly, your body is a vehicle that transports you around, and if you don’t have enough energy, it’s a problem. Historically, humans produced twice the amount of ATP compared to today, but the influx of chemical toxins has drastically reduced cellular energy production, leading to a significant decline in overall health.

The ATP Crisis: A Modern Epidemic

Humans are producing up to 75% less ATP today than a century ago. This decline is not just a number — it’s a reflection of our deteriorating health. The question remains: Why has ATP production plummeted?

The answer lies in the toxins that have permeated our environment over the past 150 years. The Industrial Revolution and subsequent advancements introduced chemical poisons into our lives, fundamentally disrupting our cellular machinery. Among these toxins, seed oils like soybean, corn and sunflower oil, stand out as primary culprits in harming your cellular energy.

Seed Oils: The Silent Destroyers of Health

Seed oils rich in polyunsaturated fatty acids (PUFAs) are one of the main drivers destroying your health, as excess consumption leads to obesity, diabetes, heart disease, cancer and dementia. These oils, often misleadingly labeled as “healthy” vegetable oils, wreak havoc on mitochondrial function. Consuming excessive amounts overloads your cells with harmful fats, crippling their ability to produce ATP.

Safe alternatives include coconut oil, ghee and beef tallow. Eating out poses a significant challenge for those striving to avoid seed oils like canola and soybean oil. One practical tip when you dine at a restaurant is to inform the server that you have a severe allergy to seed oils. Show them evidence of the dangers, and ensure the kitchen adheres to your requirements.

Most restaurants are unaware of the extent of seed oil contamination. By educating them and insisting on pure fats, you protect your health while raising awareness. The prevalence of adulterated oils, even in the case of products like extra virgin olive oil, makes vigilance essential. Additionally, cooking your own meals at home or choosing restaurants that use healthier frying fats, such as beef tallow, will significantly reduce your exposure to harmful PUFAs.

The Truth About Sugar: A Cellular Fuel

Contrary to popular belief, not all sugars are detrimental. Sugar, when used wisely, restores your energy. The key lies in understanding the type of sugar and its role in your metabolism. Real sugar — specifically glucose, also known as dextrose — is the ultimate fuel for your mitochondria. Unlike high-fructose corn syrup, which is harmful, glucose is essential for efficient energy production.

However, moderation is crucial. If you consume too much sugar, it disrupts insulin and hormonal balance. For individuals suffering from severe mitochondrial poisoning, however, glucose is a lifesaver, providing the necessary energy to sustain vital bodily functions. This nuanced understanding of sugar’s role challenges the conventional narrative that all carbohydrates are harmful.

Your Gut Microbiome: Balancing Good and Bad Bacteria

Your gut health plays a pivotal role in cellular energy and overall well-being. I explained the importance of colonocytes — cells lining your colon that rely on short-chain fatty acids like butyrate, propionate and acetate, produced by beneficial bacteria. When mitochondrial function is impaired, these colonocytes begin to die, allowing oxygen to seep back into your gut.

This shift creates an environment where pathogenic, oxygen-tolerant bacteria thrive, producing endotoxins that further damage mitochondria. This creates a vicious cycle I call the “black hole of death.”

To break free from this cycle, it’s essential to restore the balance of gut bacteria. Unfortunately, many people are unaware of the state of their microbiome, as beneficial bacteria are often overshadowed by their pathogenic counterparts. Advanced testing, though expensive, provides insights into the state of your gut health, but practical dietary adjustments are equally important.

Until an intervention targets the factors harming your colonocytes and restores optimal oxygen levels, the population of beneficial, oxygen-intolerant microbes cannot be reestablished in your gut. This mitochondrial-gut microbiome communication is necessary for health. However, when oxygen-tolerant pathogenic bacteria dominate, they outcompete the beneficial, oxygen-intolerant bacteria, preventing the production of essential metabolites needed for vitality.

Removing excess oxygen from your colon is key because, without it, even the best lifestyle practices — such as exercise, adequate sleep proper nutrition and the use of supplements — will not result in significant improvement. Simply introducing probiotics is insufficient for replenishing oxygen-intolerant microbes, as most commercially available probiotics are often non-viable.

While these probiotics offer postbiotic benefits, they do not function as true “seeds” to rebuild the appropriate microbial community. Just as a seed cannot grow in a desert, the environment within your colon must be conducive for these beneficial microbes to flourish.

Therefore, avoiding mitochondrial poisons, including seed oils and endocrine-disrupting chemicals, is essential to create the right conditions for restoring a healthy, oxygen-intolerant microbial population in your gut.

The Hidden Dangers of Plastics and Endocrine Disruptors

Beyond dietary choices, environmental toxins like plastics pose a significant threat to cellular health. Plastics produce endocrine-disrupting chemicals (EDCs) that stimulate estrogen receptors. These chemicals are pervasive, found in everyday items like water bottles and food wraps, and are linked to various health issues, including breast cancer.

EDCs disrupt hormonal balance, leading to widespread health problems. These chemicals primarily operate by activating estrogen receptors within your cells. This activation leads to an increased influx of calcium ions into your cells. Excessive intracellular calcium dramatically elevates the levels of superoxide and nitric oxide.

These reactive molecules swiftly combine to form peroxynitrite, an extremely potent oxidant stressor. The formation of peroxynitrite induces severe oxidative stress, resulting in significant cellular damage. In addition, when combined with natural estrogen, exposure to EDCs leads to estrogen overload and initiates a series of harmful events.

How EDCs Trigger Your Self-Attack Autoimmune Responses

Endocrine-disrupting chemicals (EDCs) pose a significant threat to your health, initiating a cascade of negative effects that begin at the cellular level and ripple outward to impact your entire body. This process unfolds in several interconnected stages, each building upon the last to create a perfect storm of health challenges in your system.

It all starts with your mitochondria — the powerhouses of your cells. EDCs interfere with these crucial organelles, diminishing their ability to produce the energy your cells need to function optimally. This energy deficit isn’t just a matter of you feeling tired; it has far-reaching consequences, particularly for your gut health.

Your digestive system relies on a delicate balance of beneficial bacteria, many of which thrive in an oxygen-free environment. The energy shortage caused by mitochondrial dysfunction disrupts this carefully maintained anaerobic setting in your gut. As a result, these beneficial microorganisms struggle to survive and perform their vital functions within you.

One of the key roles of these gut bacteria is the production of short-chain fatty acids. These compounds are essential for maintaining the health and integrity of your intestinal lining. They act as a primary food source for the cells that make up this barrier and help regulate the immune responses in your gut. However, when your gut bacteria are compromised due to the altered environment, their ability to produce these crucial fatty acids is severely impaired.

The absence of adequate short-chain fatty acids leads to a weakening of your intestinal barrier. This condition is often referred to as “leaky gut” or increased intestinal permeability. In this state, the tight junctions between the cells lining your intestines become loose, allowing substances that should remain within your gut to pass into your bloodstream.

This is where the situation can take a particularly concerning turn for you. Among the substances that can now penetrate your weakened gut barrier are proteins that bear a striking resemblance to structures within your own body — such as those found in your joints or neurological tissues.

When these foreign yet familiar proteins enter your bloodstream, your immune system is faced with a case of mistaken identity. It perceives these proteins as threats and mounts an attack against them.

The problem is, due to the similarity between these intruding proteins and your own body tissues, your immune response doesn’t stop at neutralizing the perceived invaders. Instead, it can turn against your own cells and tissues that share similar structures. This misdirected immune attack is the hallmark of autoimmune diseases, where your body essentially wages war against itself.

Thus, from the initial disruption of cellular energy production by EDCs, you arrive at a situation where your body’s own defense mechanisms have been tricked into causing harm to you. This complex chain of events underscores the far-reaching and interconnected nature of your body’s systems and highlights how these seemingly small disruptions can cascade into significant health challenges for you.

The challenge lies in finding safe alternatives, as conventional plastics are laden with harmful chemicals. I’m in the process of creating bio-compatible alternatives to plastics in order to help eliminate EDC exposure and promote environmental sustainability.

Electromagnetic Fields (EMFs): A Mitochondrial Poison

Another insidious threat to your cellular health today is exposure to EMFs. Unlike other toxins, EMFs permeate our environment, making them a pervasive danger that is often overlooked.

Electromagnetic frequencies describe all types of radiation, including beneficial ones like sunlight. However, the high-frequency EMFs emitted by modern devices such as cellphones, Wi-Fi routers and microwaves operate in the gigahertz range, posing significant risks to your mitochondria.

While ionizing radiation like X-rays directly damages cells by creating free radicals, EMFs cause harm through a different mechanism called non-thermal effects. These non-thermal effects disrupt cellular function without raising tissue temperatures, making the damage less visible but equally, if not more, dangerous.

EMFs interfere with mitochondria by increasing calcium ion influx into cells. Elevated calcium levels catalyze the production of harmful free radicals, leading to oxidative stress and mitochondrial dysfunction. This process mirrors the damage caused by other mitochondrial poisons, like seed oils and EDCs, creating a vicious cycle of cellular decline.

The Telecommunication Industry’s Deceptive Practices

The telecommunications industry, much like the tobacco industry before it, has employed deceptive strategies to downplay the dangers of EMFs. They used the same playbook as the tobacco industry to greenwash their products and obfuscate the real risks. The 1996 Telecommunications Act, for instance, effectively immunized these companies from liability, allowing them to continue disseminating harmful EMFs without accountability.

They promote the idea that non-ionizing radiation is safe because it doesn’t cause immediate thermal damage. This misleading narrative ignores the long-term, chronic effects of EMF exposure, which accumulate over time and contribute to a host of health problems, including cancer, neurological disorders and reduced cellular energy.

Practical Steps to Mitigate EMF Exposure

Understanding the dangers of EMFs is only the first step; taking actionable measures to reduce exposure is crucial for safeguarding your health. Here are several strategies I recommend:

1. Limit cellphone use — Avoid keeping your cellphone close to your body, especially when sleeping. Cellphones emit high levels of EMFs and prolonged exposure significantly disrupts mitochondrial function. I personally use an EMF shield tent to create a low-radiation environment during sleep, ensuring that my mitochondria remain untainted by these frequencies.
2. Reduce Wi-Fi dependency — Turn off Wi-Fi routers when not in use, especially at night. Wi-Fi is a constant source of EMFs in many households, and minimizing its operation drastically reduces overall exposure. For essential connectivity, use wired Ethernet connections instead of wireless alternatives.
3. Create EMF-free zones — Designate certain areas of your home, such as your bedroom, as EMF-free zones. By establishing a sanctuary free from electromagnetic radiation, you provide your mitochondria with the environment they need to function optimally. Simple steps like using wired devices and keeping electronic gadgets out of these areas makes a significant difference.
4. Use EMF shielding products — Investing in EMF shielding products, such as EMF-blocking phone cases or shielding tents, provides additional protection. These products help deflect or absorb harmful frequencies, safeguarding your cellular health. While not a complete solution, they offer a practical layer of defense against unavoidable EMF exposure.

Reclaiming Health: Strategies for Protection and Restoration

To break free from this cycle of mitochondrial poisoning, it is imperative to adopt comprehensive strategies that eliminate exposure to harmful toxins and support mitochondrial function. Here are several actionable steps:

1. Eliminate seed oils and processed foods — As mentioned, seed oils like soybean, corn and sunflower oil are laden with PUFAs that oxidize easily, producing toxic metabolites that damage mitochondria. By removing these oils from your diet, you reduce the primary source of mitochondrial poisoning.
2. Adopt safe fats and whole foods — Incorporate saturated fats such as coconut oil, butter, ghee and beef tallow into your diet. These fats are stable and support mitochondrial function without the harmful effects of PUFAs. Additionally, focus on whole, unprocessed foods that provide essential nutrients without the added toxins found in processed products.
3. Minimize EMF exposure — Limit your exposure to EMFs by reducing the use of wireless devices and turning off Wi-Fi when not in use. Embracing EMF shielding solutions, such as EMF-blocking phone cases and creating EMF-free zones in your home, significantly reduces cellular stress and supports mitochondrial health.
4. Optimize sun exposure — Embrace sun exposure around solar noon once you have eliminated seed oils from your diet. Proper sun exposure enhances mitochondrial energy production and supports overall health. Use minimal, protective clothing to maximize benefits while preventing skin damage.
5. Restore gut health — Addressing gut microbiome imbalances is crucial for maintaining cellular energy. Focus on consuming beneficial bacteria and limiting fiber intake if pathogenic bacteria dominate your gut. Probiotic supplements and dietary adjustments help restore a healthy balance of gut flora, supporting mitochondrial function.

The Power of Education and Advocacy

Raising awareness about the true impact of these mitochondrial poisons is essential for empowering individuals to take control of their health. Education and advocacy are crucial in countering the misinformation spread by powerful industries. By informing the public about the real dangers of seed oils, EMFs and mask mandates, we foster a movement toward healthier living and systemic change.

On an individual level, you must take proactive steps to protect your health, even in the face of pervasive EMF exposure and misleading public health directives. Simple lifestyle changes, combined with a commitment to natural health principles, significantly enhance mitochondrial function and overall well-being.

A Vision for a Healthier Future

Looking ahead, my mission is to continue developing solutions that protect and restore cellular health. These efforts aim to harmonize technological advancements with natural health practices, ensuring that progress does not come at the expense of our well-being.

The goal is to empower individuals with the knowledge and tools needed to maintain robust mitochondrial function and achieve lasting health. By addressing the root causes of mitochondrial poisoning and advocating for informed, holistic health practices, we’ll can pave the way for a future of longevity and joy.

A U.S. Department of Agriculture (USDA) report on honeybee colonies reveals a troubling trend that could have far-reaching consequences for your food supply and the environment.¹ Varroa mites have emerged as the primary threat to honeybee populations, affecting a staggering 54.8% of colonies during April through June 2024.

These parasitic mites weaken bees, making them more susceptible to diseases and reducing their ability to survive harsh conditions. The impact of varroa mites on your local ecosystem cannot be overstated, as they contribute significantly to colony losses and pose a severe challenge to beekeepers nationwide. Understanding the severity of this problem and others facing honeybees is crucial, as it directly affects pollination services essential for many crops you rely on daily.

Colony Collapse Disorder: A Persistent Threat

While there’s a glimmer of hope with a 34% decrease in colonies lost to colony collapse disorder (CCD) symptoms from January through March 2024 compared to the same period in 2023, the issue remains a significant concern.² CCD, characterized by the sudden disappearance of adult bees from the hive, continues to puzzle researchers and beekeepers alike.

The loss of 70,650 colonies to CCD symptoms in just three months highlights the ongoing struggle to maintain healthy bee populations.³ This mysterious phenomenon not only impacts honey production but also threatens the pollination of countless plants in your garden and local ecosystem. The reduction in CCD cases is encouraging, but it’s clear that more research and preventive measures are needed to protect your food security and biodiversity.

The USDA report paints a picture of constant flux in honeybee populations, with significant losses and additions throughout the year. From January through March 2024, beekeepers lost 396,820 colonies, representing a 15% decline. However, they also added 404,100 colonies during the same period, barely offsetting the losses.

This cycle of loss and renewal underscores the challenges faced by beekeepers in maintaining stable populations. The highest number of colonies lost in 2023 was during April through June, with 378,190 colonies lost.⁴ Pesticides were also named as a leading stressor in about 10% of colonies from January through June.⁵

These fluctuations have a direct impact on your local agriculture and ecosystems, as they affect the availability of pollinators for crops and wild plants alike. Understanding this dynamic is crucial for appreciating the efforts required to sustain honeybee populations and the vital services they provide.

Neonicotinoids: A Silent Killer in Your Garden

Common pesticides in your garden are contributing to the alarming decline in honeybee populations. One study shed light on how neonicotinoids, particularly thiacloprid, have long-lasting effects on honeybees even when exposed during their larval stage.⁶ Thiacloprid, once considered less toxic to bees than other neonicotinoids, is now under scrutiny for its significant impact on bee health.

The research reveals that exposure to sublethal concentrations of thiacloprid during the larval phase leads to reduced survival rates in adult bees. The exposed bees showed increased sugar-water consumption without corresponding weight gain, suggesting a disruption in their energy metabolism.⁷

This means that bees exposed to thiacloprid as larvae struggle to maintain their energy balance as adults, impacting their ability to forage and contribute to the colony’s survival.

Gut Microbiome Is a Key Player in Bee Health

Your gut health is crucial for your overall well-being, and the same is true for honeybees. The study uncovered that early-life exposure to thiacloprid significantly alters the gut microbiota of adult honeybees.⁸ On the first day after emergence, bees exposed to thiacloprid showed a dramatic reduction in gut microbial diversity. This disruption in the delicate balance of beneficial bacteria could have far-reaching consequences for bee health.

A healthy gut microbiome plays vital roles in digestion, nutrient absorption, metabolism and immunity. By disturbing this ecosystem, thiacloprid indirectly weakens bees’ defenses against pathogens and reduces their ability to extract nutrients from their food efficiently.

While the study found that the microbial diversity seemed to stabilize by the sixth day after emergence, the initial disruption during a critical period of development could have lasting effects on the bees’ overall health and resilience.⁹

From Hive to Human: The Ripple Effect of Pesticide Use

You might wonder why the health of honeybees should matter to you. The answer lies in the intricate web of ecological relationships that sustain our food systems. Honeybees are primary pollinators, playing a crucial role in global ecosystems and agricultural biodiversity. Their decline doesn’t just mean less honey; it threatens the very foundations of our food security.

Even pesticides considered “less toxic” have long-term effects that disrupt the delicate balance of nature. When you use neonicotinoids in your garden or purchase produce grown with these pesticides, you’re unknowingly contributing to a chain reaction that weakens bee colonies.

This, in turn, affects crop yields and the overall health of our ecosystems. So, your individual actions, even at the level of choosing garden products, have far-reaching consequences for the environment and, ultimately, your own well-being.

The Hidden Toll of Industrial Agriculture on Honeybees

In intensive agricultural areas, honeybees also face a rollercoaster of feast and famine as crops bloom and wither. During food shortages between mass flowerings, researchers found that worker bees start foraging at a younger age — essentially growing up too fast.¹⁰ This premature maturation comes at a steep cost, shortening the bees’ overall lifespan.

By analyzing the life histories of over 1,035 individual bees across different landscapes, scientists uncovered how food scarcity pushes young bees to become foragers earlier than normal.¹¹ While this helps the colony gather resources in the short-term, it means each worker bee lives a shorter life.

Over time, this accelerated life cycle threatens the survival of entire colonies. The findings reveal an invisible toll that modern farming practices take on bee populations, even when the effects aren’t immediately obvious. Understanding these hidden stressors and embracing alternatives like regenerative agriculture are crucial for protecting the pollinators your food supply depends on.

A Lifeline in the Agricultural Desert

Amid the sea of cropland, patches of wilderness provide a vital refuge for bees. The study, published in Science of The Total Environment, found that areas with more semi-natural habitats like meadows, hedgerows and woodlands helped buffer honeybees against the harsh effects of food shortages.¹² In landscapes with abundant natural areas, bees were able to delay foraging and live longer lives overall.

This protective effect was especially pronounced during times of scarcity between crop blooms. Bees with access to diverse wild plants maintained more normal life cycles, avoiding the premature aging seen in more barren agricultural zones.

These oases of biodiversity are critical for supporting pollinator health. Even small increases in natural habitat around farms could make a big difference for bee populations. By preserving and restoring these areas, you can help create a more hospitable environment for the bees that your food system relies on.

The Delicate Balance of a Bee’s Lifespan

The researchers uncovered an intriguing trade-off in bee development: workers that start foraging too early or too late tend to have shorter foraging careers overall. The sweet spot appears to be around 14 days old — bees that began foraging at this age had the longest productive lifespans as foragers.¹³

This delicate balance likely relates to the bees’ physiology. Those pushed to forage too young may not be physically ready for the demanding job. On the flip side, bees that delay foraging for too long may have limited time left in their natural lifespan. Understanding this optimal timing could help beekeepers and farmers better support healthy colonies.

The presence of diverse natural habitats seems to help bees hit this developmental “sweet spot” more often. By creating and supporting an environment that allows for more normal bee development, you can support more robust and resilient pollinator populations in your area.

Hope for Reversing Honeybee Decline

While the findings paint a sobering picture of honeybee health in many industrial agriculture landscapes, they also point to achievable solutions. The study showed that even modest increases in semi-natural habitat around crops have significant benefits for bee populations.¹⁴

Simple changes like planting hedgerows, establishing wildflower meadows or leaving some land fallow can make a big difference. These practices not only support bees but also provide habitat for other beneficial insects and wildlife. As a consumer, you can support these efforts by choosing products from small farms that prioritize biodiversity.

You can also create pollinator-friendly spaces in your own yard or community. By advocating for and implementing these changes, you have the power to help reverse the decline of bees and other crucial pollinators.

Take Action to Protect Bees and Your Health

Armed with this knowledge, you have the ability to make a difference. Start by avoiding the use of neonicotinoids and other synthetic pesticides in your own garden. Opt for organic, regenerative gardening methods and support small farmers who practice bee-friendly agriculture. When shopping for plants, ask nurseries if their plants have been treated with neonicotinoids and choose untreated options.

Remember, protecting bee health is ultimately about protecting your own health and the health of future generations. By making conscious choices, you’re not just helping to preserve bee populations; you’re also reducing your exposure to potentially harmful chemicals.

The research on how thiacloprid affects bee metabolism and gut health serves as a warning sign for human health as well. As you work to create a safer environment for bees, you’re also creating a healthier world for yourself and your loved ones. Every small action counts in the fight to preserve our pollinators and ensure a truly sustainable future for all.

Colony Renovation and Conservation Efforts

Meanwhile, despite the challenges, there are signs of proactive measures being taken to strengthen honeybee populations. Colony renovation is a one technique used by beekeepers to maintain and improve the health and productivity of their honeybee colonies.

This process typically involves one of two main approaches: requeening or introducing new bees. Requeening is the practice of replacing an existing queen bee with a new, often younger and more vigorous queen. This helps improve the colony’s genetics, increase egg-laying rates and enhance disease resistance.

Alternatively, beekeepers may introduce new bees through nucleus colonies (small, starter colonies) or packages (boxes containing worker bees and a queen). These methods allow beekeepers to strengthen weak colonies, replace lost bees or start entirely new hives.

By regularly renovating their colonies, beekeepers address issues such as declining populations, poor queen performance or genetic weaknesses, ultimately ensuring the long-term viability and productivity of their apiaries.

According to the USDA report, from April through June 2024, 521,790 colonies were renovated, representing 19% of the total.¹⁵ This process helps maintain genetic diversity and colony health, important factors in building resilience against threats like varroa mites and diseases.

As a consumer and member of your local community, supporting these conservation efforts through informed choices and advocacy makes a significant difference. By understanding the importance of these renovation efforts, you contribute to the long-term sustainability of honeybee populations and the ecosystems they support.

• ^{1, 2, 3, 4, 15} USDA, Honey Bee Colonies August 1, 2024
• ⁵ U.S. Right to Know August 1, 2024
• ^{6, 7, 8, 9} Genes (Basel). 2024 Aug; 15(8): 1001
• ^{10, 11, 12, 13, 14} Science of The Total Environment November 10, 2024, Volume 950, 175309

• In my interview with Calley Means, co-author of the book “Good Energy,” we discuss how tobacco companies bought major food companies in the 1980s, applying addictive strategies to food production and influencing nutritional guidelines, leading to a surge in chronic diseases
• The 1910 Flexner Report, funded by Rockefeller, reshaped medical education, emphasizing pharmaceutical interventions and marginalizing holistic approaches, setting the stage for modern health care’s limitations
• Corruption in health institutions, including conflicts of interest in research funding and guideline committees, perpetuates misguided health advice and hinders effective chronic disease management
• Reforming the health system requires removing conflicts of interest from advisory committees, restructuring financial incentives and empowering patients through grassroots advocacy and education
• A multi-pronged approach to health care transformation is necessary, including individual empowerment, new wellness-focused business models and policy changes to address the chronic disease epidemic

(Mercola)—I recently had the pleasure of interviewing Calley Means, co-author of the book “Good Energy” and a policy advisor to Robert F. Kennedy Jr. Our conversation uncovered some shocking truths about the origins of our modern food system and the dire health consequences we’re facing as a result.

However, Means’ insights into the corruption of our health institutions and his ideas for reform leave room for much optimism about the future of health in America.

The Tobacco Industry’s Secret Takeover of Our Food Supply

The tobacco industry’s covert influence on our food system is responsible for many of the processed foods that line grocery store shelves today. As Means explained:¹

“In the 1980s when you looked at the most valuable companies in the world — now it’s Microsoft and Amazon and Google — it was Philip Morris and R.J. Reynolds back then. These were two of the largest companies in the world and they had the largest cash piles, the largest balance sheet of any company in human history because smoking was such a profitable business.”

As smoking rates began to decline due to public health warnings, these tobacco giants made a calculated move. With their core business under threat, these tobacco giants used their massive cash reserves to buy up major food companies:²

“They had big piles of cash, cigarette smoking was clearly going to decline, what do they do with that cash? They bought food companies. So, we think about the 1980s as the age of Wall Street, M&A [mergers and acquisitions], Gordon Gekko. When you look at the biggest deals and the biggest Wall Street transactions in the 1980s, the two largest were cigarette companies buying food companies.”

The implications of this shift were profound:³

“By 1990, the two largest food companies in the world were R.J. Reynolds and Philip Morris. The book ‘Barbarians at the Gate,’ which is the preeminent book on the M&A deals of the 1980s, was about R.J. Reynolds buying Nabisco. And then you had Philip Morris buying Kraft, US Foods, some of the largest transactions in U.S. history.”

Making Food Addictive: The Cigarette Company Playbook

What happened next was a deliberate effort to apply tobacco industry tactics to food production:⁴

“So, what the cigarette companies did very intentionally is they shifted two departments over, they shifted their scientists over to make food more addictive. And this is an amazing situation, right? And this is documented. This is very clear what they were trying to do.

They’re going from cigarettes, which is becoming a stigmatized industry where it’s not allowed for kids, to something every single American needs — to eat starting basically at birth.”

To push their new addictive foods, the industry employed the same lobbying tactics that had kept tobacco “safe” for decades. They funded biased research from prestigious institutions like Harvard to claim sugar doesn’t cause obesity. But this wasn’t just about changing recipes.

The tobacco industry’s influence extended to shaping nutritional guidelines. This junk science was then used to create the infamous USDA food pyramid, which Means called “the most deadly document in American history.” The goal was clear: “And just as any drug provider, the business is getting people hooked, getting them hooked early, getting them hooked for a long period of time.”⁵

The Health Consequences of a Corrupted Food System

The impact of these changes on public health has been devastating. As Means pointed out:⁶

“Cancer rates actually exploded since the 1980s dramatically. So, I joke, but I’m being somewhat serious, we’d be much healthier if the cigarette companies were back to making cigarettes.

It was actually a total disaster for the metric they were trying to solve with coming down on smoking — cancer rates. By letting the cigarette industry actually get to our food, cancer rates have absolutely just exploded along with every other chronic condition.”

This history has been largely obscured from public view. When I asked how they managed to hide their involvement, Means explained that while it has been reported on, the information hasn’t been widely disseminated. He learned about it through his work in public affairs, where they openly discussed using the “tobacco playbook” for food companies.

Beyond the personal toll, this epidemic of chronic disease is threatening the economic stability of our nation:⁷

“Health care costs are going up at an increasing rate today. They’re at 20% GDP, they’re growing double the rate GDP, health care costs. They’re the largest source of U.S. inflation. They’re going to be 40% GDP … just mathematically, if these trends don’t change, we will be a fat, infertile, sick, depressed and bankrupt population, if these trends aren’t reversed.”

The Flexner Report: How American Medicine Lost Its Way

Our discussion then turned to the historical roots of America’s dysfunctional medical system. I brought up the influential Flexner Report of 1910, which Means agreed was a pivotal moment:⁸

“John D. Rockefeller, and let’s be clear, maybe with some good intentions, the medicine was the Wild West, it wasn’t … I don’t want to get into his psyche, but I want to just say what happened. As he was a top funder of modern medical education, so Johns Hopkins was one of them, and he also was the father of the modern pharmaceutical industry from a lot of his byproducts from oil.”

The Flexner Report, commissioned by Rockefeller, fundamentally reshaped medical education in America and laid the foundations of the modern medical system, dubbed “Rockefeller medicine.” Rockefeller financed the campaign to consolidate mainstream medicine, adopt the philosophies of the growing pharmaceutical industry and shutter its competition.

Rockefeller’s crusade caused the closure of more than half of U.S. medical schools, fostered public and press scorn for homeopathy, osteopathy, chiropractic, nutritional, holistic, functional, integrative and natural medicines, and led to the incarceration of many practicing physicians. It emphasized a reductionist approach that siloed different conditions and focused on pharmaceutical interventions. As Means explained:⁹

“That report said anything about nutrition, anything about holistic, is not serious science. Serious science is siloing a condition, naming it once somebody already got sick, and then drugging it or committing surgery. And then that has really infiltrated medical education.”

Biology didn’t change just because Rockefeller was pressured under monopoly threats from the U.S. government to advert from oil and shift into pharmaceuticals. Biology still remains the same and requires treating the causes of disease, which we in no way, shape or form do with our current medical paradigm.

Further, this paradigm shift left most physicians woefully unprepared to deal with the chronic disease epidemic plaguing the U.S. today. Our medical system excels at acute interventions but struggles to address the root causes of ongoing health issues. A key factor in perpetuating this crisis is the corruption of our health institutions, which leads to dangerously misguided health advice.

“The problem is that the majority of NIH [National Institutes of Health] grants go to conflicted researchers, that the FDA drug approval department is 75% funded by pharma, that the USDA Guideline Committee on Nutrition — 95% of the advisors are funded by food or pharma,” Means says, adding:¹⁰

“The American Diabetes Association, which accepts money from Coca-Cola, is dictating standards of care, saying that Type 2 diabetes is nonreversible and basically just a drug deficiency. It is not. It is reversible and we just need a correct accounting of why people are getting diabetes and how to potentially reverse it.”

Strategies to Transform American Health

Despite the dire situation, Means remains optimistic about our ability to turn things around. He outlined a strategy for transforming American health, including fixing corrupted medical guidelines. Ideally, the first step is to remove conflicts of interest from the bodies that set medical guidelines and research priorities. As Means put it:¹¹

“Within a week we can do this — make it that there cannot be conflicts on these key medical advisory committees. What happens then? We actually get a report on what glyphosate is doing to us, we actually get reports on standards of care and tell the American Diabetes Association to stop dictating completely corrupt guidelines.”

While Means encourages this top-down approach to reforming the system, it’s a challenge because these regulatory agencies have been taken over by the very industries they’re supposed to be regulating. This occurred decades ago, and it’s getting worse as time goes on. Lobbying efforts and new rules, legislation, is controlled.

It’s almost impossible in the current state to defeat this system, so the approach I’ve taken is to go from the bottom up — go to the people directly with solutions. Fortunately, technology is emerging that allows us to have the manpower, or at least the AI power, to help people understand what they need to do to achieve optimal health.

Part of Means’ plan also involves restructuring the financial incentives in health care. Currently, the system profits from keeping people sick and managing chronic conditions rather than preventing or reversing them.

The Power of Grassroots Action

He also emphasizes the need to educate and empower patients directly, which aligns closely with my own approach of providing people with actionable health information, and cleaning up our food supply. Means believes that with the right political will, significant changes could be made quickly:¹²

“The president tomorrow can sign an executive order saying that the USDA Nutrition Guideline Committee can’t take money from food companies. The president tomorrow can sign an executive order saying that NIH cannot go to researchers with conflicts of interest. Tomorrow the FDA can be disentangled from the pharmaceutical industry.”

While I’m skeptical about the ease of implementing such changes given the entrenched interests opposing them, the power of grassroots action remains. Means is working to build grassroots momentum through his nonprofit, EndChronicDisease.org:¹³

“We have thousands of people coming and taking action. You can sign up and email your congressperson and call them. These basics, that’s what pharma does.

When there’s a bill threatening pharma, they do this grassroots advocacy where they have a bunch of old people call members of Congress and say, ‘Don’t take my drugs away.’ That matters … As I meet with members of Congress I hear a lot, ‘Our phones aren’t ringing on this issue.’ So, we’re getting the phones ringing on this issue.”

Means is also taking concrete steps to improve the situation through his company TrueMed. They’re working within the current system to expand access to preventative health measures. This innovative approach allows people to use tax-advantaged health savings accounts to invest in their wellbeing proactively, rather than just paying for drugs and procedures after they get sick.

The Spiritual Dimension of Health

By making chronic disease a politically resonant issue, we can drive real change and create the political pressure needed to enact real reforms. However, a point that’s central to my philosophy is the connection between physical health and spiritual growth. When you’re truly healthy, you’re better able to connect with your intuition and fulfill your higher purpose. It’s difficult to do that when you’re not healthy.

Ultimately, it will take a multi-pronged approach to truly transform our health system — empowering individuals with information, developing new technologies and business models to support wellness, and pushing for policy changes at the highest levels.

If you’re inspired to get involved, I encourage you to check out Means’ work at TrueMed.com and EndChronicDisease.org. By adding your voice to this growing movement, we can build the momentum needed to create real, lasting change in U.S. health care.

Remember, your health is your most valuable asset. By taking control of your own well-being and advocating for systemic reforms, you’re not just improving your own life — you’re contributing to a healthier, more vibrant future for all.

• ^{1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13} Brighteon, Mercola, How Big Tobacco Captured and Transformed the Food Industry for Worse — Interview with Calley Means

Food goes beyond providing energy — it’s essential for proper nutrition. Yet, many people fail to get the essential micronutrients they need. The problem often lies in food quality rather than quantity. People are consuming energy-dense, nutrient-poor foods, setting them up for an excess of omega-6 fats from seed oils as well as added sugars, while missing out on vital micronutrients.

Micronutrient deficiencies are a prevalent form of malnutrition, leading to serious consequences like pregnancy complications, weakened immunity and increased risk of diseases. While past studies have investigated nutrient deficiencies and supplies, there has been no comprehensive global assessment of micronutrient intake inadequacies until now.

A recent study published in The Lancet Global Health¹ addresses this gap by evaluating whether current intake levels meet recommended health standards, focusing on deficiencies across different ages and genders. Their findings highlight an alarming trend — over half of the global population is deficient in the necessary micronutrients for optimal health.

Global Study Reveals Alarming Widespread Micronutrient Inadequacies

The study,² conducted by researchers at Harvard T.H. Chan School of Public Health and the University of California, Santa Barbara (UCSB), used data from 31 countries to model global nutrient needs. They applied these models to a dataset from 185 countries, estimating nutrient deficiencies for 99.3% of the world’s population. Fifteen essential nutrients, including calcium, B vitamins and vitamin C, were evaluated across different age and gender groups.

“Our study is a big step forward,” said co-lead author Christopher Free, Ph.D., a research professor at the University of California, Santa Barbara (UCSB), in a news release.³ “Not only because it is the first to estimate inadequate micronutrient intakes for 34 age-sex groups in nearly every country, but also because it makes these methods and results easily accessible to researchers and practitioners.” According to the authors:⁴

“More than 5 billion people do not consume enough iodine (68% of the global population), vitamin E (67%) and calcium (66%). More than 4 billion people do not consume enough iron (65%), riboflavin (55%), folate (54%) and vitamin C (53%).

Within the same country and age groups, estimated inadequate intakes were higher for women than for men for iodine, vitamin B12, iron and selenium and higher for men than for women for magnesium, vitamin B6, zinc, vitamin C, vitamin A, thiamin and niacin.”

These results underscore the widespread nature of micronutrient deficiencies globally, revealing distinct patterns related to sex and geographic location. “We hope this analysis … improves understanding of global micronutrient inadequacy so that public health interventions can more effectively address deficiencies,” the researchers concluded.

Common Nutrient Deficiencies in the US

According to data from the National Health and Nutrition Examination Surveys (NHANES), an estimated 31% of the U.S. population is at risk of developing one or more micronutrient deficiencies.⁵ The most common nutrient deficiencies include vitamins D, B1, B2, B3 and B12, A, C, E, calcium, magnesium and iodine.

Although the study didn’t include vitamin D since it primarily focused on nutrients obtained through diet, vitamin D deficiency remains a significant concern in the U.S., impacting approximately 35% of the population.⁶ Vitamin D is a fat-soluble vitamin that is essential for various physiological functions, including calcium absorption, bone health and immune function.

While it’s found naturally in some foods, your body endogenously produces vitamin D when your skin is exposed to ultraviolet rays from the sun.

However, many factors limit this natural production, including living in northern latitudes, having darker skin, spending most time indoors or using sunscreen. Additionally, as people age, their skin becomes less efficient at producing vitamin D from sun exposure.⁷

The ideal way to increase your vitamin D levels is through sensible sun exposure. On a typical sunny day,⁸ your body produces up to 25,000 international units IU of vitamin D. However, it’s important to approach sun exposure with care, especially if your diet is high in seed oils (rich in linoleic acid, or LA).

These oils migrate to your skin and oxidize when exposed to sunlight, causing inflammation and DNA damage, which makes you more prone to sunburn. If you’re on a high-LA diet, I recommend avoiding intense sun exposure until you’ve reduced your seed oil intake for four to six months. As you reduce your LA intake, slowly increase your time outdoors. You’ll eventually be able to enjoy an hour or more during peak sunlight hours.

If you’re unable to get adequate sun exposure, vitamin D3 supplementation is a wise choice. For health and disease prevention, aim for a level between 60 ng/mL and 80 ng/mL. In Europe, the measurements you’re looking for are 150 to 200 nmol/L, respectively.

To determine how much vitamin D3 you need to take, measure your vitamin D level, ideally twice a year. Your ideal dose is whatever it takes to keep you within that 60 ng/mL to 80 ng/mL range. It’s also important to remember that calcium, vitamin D3, magnesium and vitamin K2 must be properly balanced, as these four nutrients work together.

Vitamin B1, B2 and B3

Vitamin B1, also known as thiamine, is used by nearly all your cells and is essential for several functions in the body, including energy production, nerve function, heart health, cognition, digestion and immune function.⁹

While thiamine deficiency is often the result of alcohol misuse, chronic infections, poor nutrition and/or malabsorption, research suggests vitamin B1 availability has dramatically declined throughout the food chain in recent years,¹⁰ and that naturally affects your ability to get sufficient thiamine from your diet.

Adult men and women need 1.2 and 1.1 milligrams (mg), respectively, each day.¹¹ If you have symptoms of thiamine deficiency, you might need higher doses. For tips on how to boost your vitamin B1 levels, I recommend reading my article, “Common Signs of Vitamin B1 Deficiency.”

Similarly, vitamin B2, commonly known as riboflavin, is important for energy production, cellular function and metabolism. As a coenzyme in various redox reactions, riboflavin is essential for converting food into usable energy. It plays a central role in the electron transport chain, where it helps produce ATP, the primary energy source for the body. This makes riboflavin particularly important for overall energy levels and metabolic health.^12,13

To increase your riboflavin levels, consume a diet rich in riboflavin sources. Good dietary sources include grass fed dairy products, lean meats like grass fed beef tenderloin, organic low-PUFA eggs, cremini and portabella mushrooms, and green leafy vegetables like spinach and beet greens.

Vitamin B3 exists in two primary forms — niacin (nicotinic acid) and niacinamide (nicotinamide). Both are essential to human health and play important roles in cellular metabolism, converting the food you eat into energy.

These forms of vitamin B3 also serve as precursors for the coenzymes nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP), which are vital for energy production, DNA repair and cell signaling.

For optimal health, I recommend taking 50 mg of niacinamide three times a day. This dosage has been shown to optimize energy metabolism and boost NAD+ levels.

The problem with taking too much vitamin B3, whether in the form of niacin or niacinamide, is that it might backfire and contribute to cardiovascular disease as demonstrated in a study conducted by the Cleveland Clinic.¹⁴ I talked more about this in my article, “Vitamin B3 Boosts Muscle Mass, Improves Glucose Control.” As for food sources, vitamin B3 is found in grass fed beef and beef liver, bananas and mushrooms.¹⁵

Vitamin B12

Also known as cobalamin, vitamin B12 is a water-soluble vitamin that plays a role in numerous biochemical reactions and neurological functions in your body, including DNA synthesis. Your body can’t make vitamin B12 on its own, so it must be obtained via your diet or supplementation.¹⁶

According to NHANES data, about 3.6% of U.S. adults aged 19 and older have a vitamin B12 deficiency, with the rate slightly increasing to 3.7% in those 60 and older. However, vitamin B12 insufficiency is more common, affecting around 12.5% of adults aged 19 and older and 12.3% of those 60 and older. During pregnancy, vitamin B12 levels often decrease, sometimes falling below normal levels.¹⁷

Vitamin B12 is found almost exclusively in animal foods, such as grass fed beef and beef liver, lamb, organic eggs and grass fed dairy products. The few plant foods that are sources of B12 are actually B12 analogs that block the uptake of true B12, so do not make the mistake of thinking you can rely on vegan sources for all your B12 needs.

If you rarely eat the foods listed, consider using nutritional yeast. It’s high in B12 and has a cheesy flavor that works well on any number of dishes. One 16-gram serving (just over 2 tablespoons) provides 24 micrograms of natural vitamin B12.¹⁸ Advancing age diminishes your body’s ability to absorb B12 from food, so you might want to consider supplementation as you get older.¹⁹

Vitamins A and C

An estimated 51% of adults are not consuming enough vitamin A,²⁰ increasing their risk of degenerative diseases like macular degeneration, a leading cause of blindness in the U.S.²¹ Vitamin A is also responsible for immune system function as well as cellular growth and differentiation.²²

Vitamin A is a group of nutrients that falls into two different categories — retinoids found in animal foods and carotenoids found in plant foods. The two are chemically different and provide different health benefits, but both are necessary for optimal health. Plant foods high in beta-carotene include sweet potatoes, carrots, cantaloupe and mangoes. Animal foods rich in vitamin A include liver, egg yolks and grass fed butter.²³

Vitamin C, also known as ascorbic acid, is known for its potent antioxidant properties and role in numerous bodily functions, including tissue growth and repair, collagen synthesis, iron absorption and immune function.²⁴

A wide variety of foods are high in vitamin C, including red pepper, parsley, broccoli, kiwi, strawberries, guava, tomato and all citrus fruits. You’ll get significant amounts of vitamin C from your diet if you eat these foods on a daily basis.

In addition to dietary sources, I highly recommend keeping liposomal vitamin C in your medicine cabinet, particularly for acute viral illnesses. If I were to become acutely ill, I would take 4 grams of liposomal vitamin C every hour until feeling better, then start decreasing the dosage slowly over a few days once symptoms improve.

Vitamin E

Vitamin E is a fat-soluble vitamin with potent antioxidant properties, protecting your cells from free radical damage. It also supports the production of red blood cells, regulates your body’s use of vitamin K (which is important for heart health) and is involved in your immune function and cell signaling.²⁵ Additionally, it protects your body against damage caused by linoleic acid and estrogen.

In the U.S. alone, approximately 88.5% of the population fails to reach the recommended dietary allowance (RDA) of vitamin E.²⁶ To increase vitamin E levels, eat foods rich in this nutrient, including spinach, pumpkin, asparagus, red bell peppers, tomatoes, kiwi and mango.²⁷

Some health authorities recommend vegetable oils, seeds and nuts as good sources,²⁸ but these are actually terrible due to their high LA content. Beans — another good source of vitamin E — are also problematic for many due to their high lectin content.

Supplementation is also an option to increase your levels, but it’s important to look for a real vitamin E supplement and not synthetic. What you’re looking for is “d alpha tocopherol.” I go into detail about this in “Vitamin E Helps Decrease Your Cancer Risk.”

Calcium and Magnesium

Over 40% of the U.S. population fails to meet their calcium needs through diet alone, putting them at increased risk of bone-related issues such as osteoporosis and fractures.²⁹ Calcium is also essential for muscle contraction, nerve transmission and blood clotting.³⁰

A deficiency in calcium coupled with excess phosphorus intake due to phosphate additives in processed food poses additional risk, as it disrupts your calcium-to-phosphorus ratio, which leads to calcification of the vascular system and cardiovascular problems.³¹

Some good dietary sources of calcium to increase your levels include grass fed dairy products like yogurt, milk and cheese made from animal rennet. Some vegetables contain this mineral as well, such as collard greens, spinach, turnip greens, kale, cooked taro root and bok choy.³²

Estimates suggest that over half of the U.S. population also aren’t getting enough magnesium from their diet.³³ While the minimum amount needed to avoid deficiency is about 150 to 180 milligrams per day, optimal levels are closer to 600 milligrams per day. For reference, the RDA ranges from 310 to 420 milligrams per day, depending on age and sex.³⁴

Some good dietary sources of magnesium include dark chocolate, leafy greens, potatoes (peeled and boiled) and plain organic yogurt, to name a few. Avocados are also commonly recommended as a good source of this mineral, but they’re high in monounsaturated fat (MUFAs), which harms your metabolic function if consumed in excess.

Iodine

Iodine is an essential trace mineral that plays a role in the production of thyroid hormones, which regulate metabolism, growth and development. Adequate iodine intake is vital for maintaining healthy thyroid function and reducing the risk of disorders such as goiter and hypothyroidism. In addition, iodine is important for healthy bone and brain development during pregnancy and infancy.³⁵

Foods that contain higher amounts of iodine include sea vegetables, such as kelp, kombu and wakame.³⁶ Kelp has the highest amount of any food and just one serving gives you four times the recommended daily allowance. Organic, grass fed butter is another good source of iodine. Iodized salt also increases your levels if you don’t avoid eating it in the mistaken belief that it’s bad for your heart.

Will Taking a Multivitamin Help with Nutrient Deficiencies?

A diet rich in whole, nutrient-dense foods is key to avoiding nutrient deficiency. However, multivitamins help address gaps if you’re not eating right or if you suspect you have deficiencies. Research³⁷ from Oregon State University found that older men who took multivitamins showed improved nutritional biomarkers compared to those who took a placebo.

In fact, some participants in the placebo group had decreased nutrition markers, indicating that diet alone might not be sufficient, particularly for maintaining vitamin and carotenoid levels.³⁸ Multivitamins also benefit memory in older adults. One study³⁹ found that daily use could improve memory performance comparable to reversing about three years of age-related decline compared to a placebo.

If you’re planning to take multivitamins, it’s generally recommended to take half your daily dose in the morning, with breakfast, and the other half with your main meal. Remember, though, that multivitamins should complement, not replace, a healthy diet.

Dietary supplements are meant to support a balanced lifestyle, not substitute for it. Consider consulting with a holistic health professional to identify specific nutrient deficiencies and tailor your supplement and food choices to address them.

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