• Ozempic and similar weight loss drugs have been linked to 162 deaths in the U.S., with adverse reactions increasing by 40% in six months as usage expands
• These medications are associated with serious side effects, including pancreatitis, bowel obstruction and stomach paralysis, with 80% to 90% of users experiencing at least one adverse event
• Studies have found a significant link between semaglutide (the active ingredient in Ozempic) and suicidal ideation, particularly in patients also taking antidepressants or antianxiety medications
• Emerging reports indicate severe kidney problems in some patients using these weight loss drugs
• Akkermansia, a beneficial gut bacteria, is a natural alternative to stimulate GLP-1 production, offering similar benefits without the risks associated with drugs like Ozempic

(Mercola)—Glucagon-like peptide-1 (GLP-1) receptor agonists, including semaglutide — the active ingredient in Ozempic and Wegovy — have taken the world by storm. Originally developed for Type 2 diabetes, these drugs’ weight loss properties quickly caught the attention of researchers and the public alike.

Their effectiveness in shedding pounds has led to a global shortage, with an estimated 20 million people using them annually.¹ But as with any quick fix, there’s often a catch. According to data from the U.S. Food and Drug Administration’s (FDA) Adverse Event Reporting System (FAERS), these medications have been linked to 162 deaths in the U.S.²

The Daily Mail reports that fatalities mentioning weight loss drugs have increased by 40% in just six months, jumping from 117 to 162 reported deaths.³ This sharp rise coincides with the expanding use of these medications, as more formulations hit the market and off-label prescriptions become commonplace.

However, your risk doesn’t disappear simply because you’re using these drugs as directed. The FAERS data show that adverse reactions occur in patients using these medications for their approved purposes, whether for diabetes management or weight loss.

Ozempic-Related Deaths and ‘Serious’ Reactions on the Rise

The FAERS database reveals a disturbing trend in adverse reactions to weight loss drugs containing semaglutide and tirzepatide (used in Mounjaro and Zepbound). Since 2018, there have been 62,000 reported reactions to these medications in the U.S.⁴

What’s particularly alarming is that 46,000 of these reports — nearly three-quarters of the total — occurred after 2022. This coincides with the increased availability and marketing of these drugs. Of the 162 reported deaths, 94 were linked to semaglutide-based drugs, while 68 were associated with tirzepatide medications. It’s worth noting that in 2023, tirzepatide was linked to nearly twice as many adverse reactions as semaglutide.⁵

The FAERS system has recorded 10,000 “serious” reactions to these weight loss drugs, defined as events resulting in hospitalization or life-threatening conditions. These aren’t just minor inconveniences; they’re significant medical events that could have long-lasting impacts on your health.

For instance, Daily Mail reports a case of a 30-year-old man on Ozempic who was hospitalized with pancreatitis, an inflammation of the pancreas that causes severe abdominal pain. In another case, a 49-year-old woman taking Ozempic experienced mania and a dangerous surge in blood pressure, requiring hospitalization.⁶

While 1.7% of Americans — approximately 5.6 million people — were prescribed weight loss drugs in 2023, recent surveys suggest that number has grown to about 6% of U.S. adults, or 15.5 million people.⁷ This rapid increase in usage means more individuals are exposed to the serious side effects.

Ozempic Linked to Suicidal Ideation

A comprehensive study analyzing the World Health Organization’s database of adverse drug reactions uncovered more troubling findings about Ozempic.⁸ The research, which looked at over 36.1 million reports, found a significant link between semaglutide and suicidal ideation.

Out of 30,527 total reports for semaglutide, 107 cases of suicidal or self-injurious reactions were identified, and the association remained significant even after accounting for other factors. The research revealed a 45% increased risk of suicidal ideation in patients taking semaglutide compared to other medications.⁹

Further, people taking antidepressants or antianxiety medications alongside semaglutide were at an even higher risk of reporting suicidal thoughts — a 150% to 300% increase in suicidal ideation was found among this group.¹⁰

A study in Frontiers in Psychiatry revealed insights into semaglutide’s impact on your emotional state and psychological well-being.¹¹ The drug’s main component targets GLP-1 receptors, which are present not just in your digestive tract but also in critical brain areas. These regions, such as the lateral septum and hypothalamus, are essential for managing emotions, reward systems and appetite control.

Semaglutide’s interaction with these receptors modifies the functioning of neural pathways involved in these processes. Particularly noteworthy is its influence on dopamine, a neurotransmitter closely associated with mood regulation and reward perception.

Research indicates that stimulating GLP-1 receptors may enhance dopamine transporter expression, leading to decreased free dopamine levels in specific brain regions. This shift in dopamine signaling might lead to alterations in your mood, motivation levels, and even how you experience pleasure.

Up to 90% of Ozempic Users Experience an Adverse Event

The most common side effects linked to Ozempic and similar drugs are gastrointestinal, including nausea, diarrhea and vomiting. In clinical trials, a staggering 80% to 90% of participants experienced at least one adverse event.¹² Though most were mild to moderate, they led some people to discontinue the medication.

Further, these drugs are intended for long-term use — stopping them often results in weight regain — further increasing the risk of side effects over time. While nausea and diarrhea might seem manageable, more severe health risks, including pancreatitis, are a real concern. A study of 16 million patients found that those taking liraglutide or semaglutide had over nine times the risk of developing pancreatitis compared to those on other weight loss medications.¹³

The same study showed a four-fold increase in the risk of bowel obstruction and nearly four times the risk of gastroparesis (stomach paralysis). Gallbladder issues are another significant concern. Clinical trials revealed higher rates of gallstones and cholecystitis (gallbladder inflammation) in people taking these drugs.¹⁴

While rare, some patients required surgery for these complications. It’s also worth noting that these medications increase heart rate.¹⁵ There’s also the potential for aspiration during anesthesia. These drugs slow down stomach emptying, which means you may still have food in your stomach even after fasting for the recommended time before surgery. This increases the risk of aspiration pneumonia, a serious complication.

The FDA has also warned that Ozempic causes an intestinal blockage called ileus,¹⁶ which can lead to life-threatening complications if not treated promptly.

Another Ozempic Dark Side: Kidney Damage

Troubling reports of severe kidney problems due to Ozempic are also emerging. Research published in the Clinical Kidney Journal reported two patients experienced acute interstitial nephritis (AIN), a serious kidney inflammation, after starting semaglutide.¹⁷

One case even involved focal segmental glomerulosclerosis (FSGS), a type of kidney scarring. These findings suggest these drugs pose significant risks to your kidney health, especially if you have pre-existing kidney issues. The first case involved a 68-year-old woman with chronic kidney disease who started semaglutide for weight loss.

Within weeks, she developed severe nausea and vomiting, leading to a dramatic increase in her creatinine levels — a key indicator of kidney function. Even after stopping the medication, her kidney function worsened upon restarting it. A biopsy confirmed acute interstitial nephritis, likely triggered by semaglutide.¹⁸

The second case was even more alarming. A 49-year-old woman with no prior kidney issues developed severe swelling and protein in her urine after three months on semaglutide. Her kidney biopsy revealed not only AIN but also FSGS, a condition that can lead to kidney failure.

The study authors suggest that risk factors for these complications may include chronic kidney disease, advanced age, obesity and concurrent use of other medications that can affect the kidneys. A review of the FDA’s adverse event reporting system revealed 2,375 kidney-related events associated with GLP-1 drugs between 2010 and 2022.¹⁹

Acute kidney injury was the most common, accounting for nearly 59% of reports. Other reported issues included high blood pressure, electrolyte imbalances and, in rare cases, severe protein loss in the urine.

Akkermansia: A Natural Ozempic Alternative

Sustainable weight loss involves more than just a quick fix. It requires a holistic approach that considers your overall health, including your mental well-being. As tempting as these drugs might seem, especially with their popularity on social media, it’s crucial to make decisions based on scientific evidence rather than anecdotal reports or trends. Your health is too important to gamble with unproven or potentially dangerous solutions.

In my interview with Dr. Colleen Cutcliffe, a molecular biology scientist and the CEO and co-founder of Pendulum, a company that creates microbiome products, she explained that, instead of using Ozempic, you can naturally elevate your GLP-1 levels by increasing the presence of the beneficial bacteria Akkermansia in your gut:

“What happens in your body naturally, if you’ve got all the right microbes, is that you eat a meal, your microbiome metabolizes that food and generates postbiotics [excretions from beneficial bacteria] like butyrate [and] a protein called P9. Some of these postbiotics then signal your body to produce GLP-1.

All that signaling is happening from the microbiome directly to the L cells. And so you eat a meal, your microbiome digests them, these postbiotics get created and tell your L cells, ‘Hey, go produce GLP-1,’ and then you get a spike in GLP-1 in your body.

GLP-1 stimulates your body too. It says, ‘We’ve got to metabolize the sugar in the bloodstream, release insulin.’ It also signals to your brain, ‘We just ate, we’re full, we don’t need to eat again.’ After a period of time, GLP-1 goes down — until the next time you eat a meal. Then it spikes again.

So that’s the natural way of things. There are only two strains that have been published, to date, that have been shown to be able to stimulate L cells to produce GLP-1, and one of them is Akkermansia. It actually secretes three different [postbiotics] that stimulate L cells to produce GLP-1.

So, what’s been found is that if you are low or missing Akkermansia, your body is not naturally producing as much GLP-1 as it’s supposed to be. By giving people back Akkermansia, you can now have these physiological benefits of reducing A1C and lowering blood glucose spikes.

To be clear, the natural GLP-1 you produce is different from the drug. The drug is a mimic. It’s an analog. It looks like GLP-1. It gets injected into the bloodstream directly, which means that rather than the natural spike after you eat [followed by a decline], the [drug] is keeping those levels really high all the time.

So, this signaling of ‘we got to metabolize sugar in the blood and we’re full, we just ate’ is going on constantly. That’s why people experience these incredible, amazing overnight effects because that’s how those drugs are working. But if you actually have the right microbes, you can generate your body’s natural GLP-1 and get back into this natural cycle.”

Many People Are Lacking Akkermansia

Research published in Nature Microbiology found that Akkermansia increased thermogenesis and GLP-1 secretion in mice fed a high-fat diet.²⁰ While Akkermansia plays a vital role in maintaining intestinal health, many individuals have insufficient levels due to compromised mitochondrial function and oxygen leakage in the gut.

One of Akkermansia’s primary functions is the production of short-chain fatty acids (SCFAs), including butyrate. These fatty acids serve as fuel for your colonocytes, which in turn produce mucin, a gel-like protective substance that coats your gut lining.

SCFAs also help remove oxygen from your colon, creating an environment where beneficial bacteria can flourish. Mucin acts as a barrier, shielding intestinal cells from damage, harmful microorganisms and digestive irritants.

Additionally, mucin enhances your immune system. It contains antibodies and antimicrobial peptides that help fight infections. Mucin also functions as a trap for potential pathogens, facilitating their elimination through the digestive process. Akkermansia is so beneficial that it should, ideally, constitute about 10% of your gut microbiome.

Make Sure Live Akkermansia Probiotics Reach Your Colon

When selecting Akkermansia probiotics, opt for products with bacterial counts in the billions rather than millions. Generally, a higher bacterial count is beneficial, but there’s an important caveat: the delivery method is crucial.

Look for probiotics in delayed-release capsules. This feature is essential because it ensures the beneficial bacteria have a higher likelihood of reaching your colon alive. Without this protective mechanism, most of the bacteria may not survive the journey through your digestive system.

Akkermansia are very sensitive to oxygen. This makes their journey through your digestive system very challenging. These beneficial microbes thrive in an oxygen-free environment, and even a brief exposure to oxygen can be fatal for them. This trait makes the delivery method of Akkermansia supplements crucial to their effectiveness.

In fact, a lower-dose probiotic (in the hundreds of thousands of bacteria) that successfully reaches your colon can be more effective than a high-dose product (with hundreds of billions of bacteria) that doesn’t make it to its intended destination. Remember, when it comes to probiotics, successful delivery to the colon is just as important as the initial dosage.

Understanding this helps you choose the most effective supplement. You want to nurture your gut microbiome with live, active Akkermansia, as dead or inactive ones won’t do you as much good as they don’t reproduce.

If you want to use Akkermansia supplements, look for ones with advanced, dual-timed release capsules or microencapsulation. These technologies keep Akkermansia dormant and protected until it reaches your colon, usually in two to four hours.

To maximize its effectiveness, take it on an empty stomach, ideally first thing in the morning after an overnight fast. Wait at least one to two hours before eating to reduce transit time, allowing the bacteria to reach your colon faster — usually within two hours. This will greatly increase the number of live bacteria that make it to your colon.

Avoid taking probiotics with food, as this can extend your transit time to over eight hours, likely killing the bacteria long before they reach your colon. Being mindful of when and how you take your Akkermansia probiotic will maximize the benefits of this powerful probiotic.

• ^1, 8, 9 JAMA Netw Open. 2024 Aug 20;7(8):e2423385
• ^{2, 3, 4, 5, 6, 7} Daily Mail September 8, 2024
• ¹⁰ ZeroHedge August 21, 2024
• ¹¹ Front Psychiatry. 2023 Aug 29;14:1238353
• ^{12, 13, 14, 15} Obes Pillars. 2024 Aug 31;12:100127
• ¹⁶ U.S. FDA, Drug Safety-related Labeling Changes, Ozempic September 22, 2023
• ^17, 18, 19 Clin Kidney J. 2024 Aug 13;17(9):sfae250
• ²⁰ Nature Microbiology volume 6, pages 563–573 (2021)

• Ozempic and similar weight loss drugs have been linked to 162 deaths in the U.S., with adverse reactions increasing by 40% in six months as usage expands
• These medications are associated with serious side effects, including pancreatitis, bowel obstruction and stomach paralysis, with 80% to 90% of users experiencing at least one adverse event
• Studies have found a significant link between semaglutide (the active ingredient in Ozempic) and suicidal ideation, particularly in patients also taking antidepressants or antianxiety medications
• Emerging reports indicate severe kidney problems in some patients using these weight loss drugs
• Akkermansia, a beneficial gut bacteria, is a natural alternative to stimulate GLP-1 production, offering similar benefits without the risks associated with drugs like Ozempic

(Mercola)—Glucagon-like peptide-1 (GLP-1) receptor agonists, including semaglutide — the active ingredient in Ozempic and Wegovy — have taken the world by storm. Originally developed for Type 2 diabetes, these drugs’ weight loss properties quickly caught the attention of researchers and the public alike.

Their effectiveness in shedding pounds has led to a global shortage, with an estimated 20 million people using them annually.¹ But as with any quick fix, there’s often a catch. According to data from the U.S. Food and Drug Administration’s (FDA) Adverse Event Reporting System (FAERS), these medications have been linked to 162 deaths in the U.S.²

The Daily Mail reports that fatalities mentioning weight loss drugs have increased by 40% in just six months, jumping from 117 to 162 reported deaths.³ This sharp rise coincides with the expanding use of these medications, as more formulations hit the market and off-label prescriptions become commonplace.

However, your risk doesn’t disappear simply because you’re using these drugs as directed. The FAERS data show that adverse reactions occur in patients using these medications for their approved purposes, whether for diabetes management or weight loss.

Ozempic-Related Deaths and ‘Serious’ Reactions on the Rise

The FAERS database reveals a disturbing trend in adverse reactions to weight loss drugs containing semaglutide and tirzepatide (used in Mounjaro and Zepbound). Since 2018, there have been 62,000 reported reactions to these medications in the U.S.⁴

What’s particularly alarming is that 46,000 of these reports — nearly three-quarters of the total — occurred after 2022. This coincides with the increased availability and marketing of these drugs. Of the 162 reported deaths, 94 were linked to semaglutide-based drugs, while 68 were associated with tirzepatide medications. It’s worth noting that in 2023, tirzepatide was linked to nearly twice as many adverse reactions as semaglutide.⁵

The FAERS system has recorded 10,000 “serious” reactions to these weight loss drugs, defined as events resulting in hospitalization or life-threatening conditions. These aren’t just minor inconveniences; they’re significant medical events that could have long-lasting impacts on your health.

For instance, Daily Mail reports a case of a 30-year-old man on Ozempic who was hospitalized with pancreatitis, an inflammation of the pancreas that causes severe abdominal pain. In another case, a 49-year-old woman taking Ozempic experienced mania and a dangerous surge in blood pressure, requiring hospitalization.⁶

While 1.7% of Americans — approximately 5.6 million people — were prescribed weight loss drugs in 2023, recent surveys suggest that number has grown to about 6% of U.S. adults, or 15.5 million people.⁷ This rapid increase in usage means more individuals are exposed to the serious side effects.

Ozempic Linked to Suicidal Ideation

A comprehensive study analyzing the World Health Organization’s database of adverse drug reactions uncovered more troubling findings about Ozempic.⁸ The research, which looked at over 36.1 million reports, found a significant link between semaglutide and suicidal ideation.

Out of 30,527 total reports for semaglutide, 107 cases of suicidal or self-injurious reactions were identified, and the association remained significant even after accounting for other factors. The research revealed a 45% increased risk of suicidal ideation in patients taking semaglutide compared to other medications.⁹

Further, people taking antidepressants or antianxiety medications alongside semaglutide were at an even higher risk of reporting suicidal thoughts — a 150% to 300% increase in suicidal ideation was found among this group.¹⁰

A study in Frontiers in Psychiatry revealed insights into semaglutide’s impact on your emotional state and psychological well-being.¹¹ The drug’s main component targets GLP-1 receptors, which are present not just in your digestive tract but also in critical brain areas. These regions, such as the lateral septum and hypothalamus, are essential for managing emotions, reward systems and appetite control.

Semaglutide’s interaction with these receptors modifies the functioning of neural pathways involved in these processes. Particularly noteworthy is its influence on dopamine, a neurotransmitter closely associated with mood regulation and reward perception.

Research indicates that stimulating GLP-1 receptors may enhance dopamine transporter expression, leading to decreased free dopamine levels in specific brain regions. This shift in dopamine signaling might lead to alterations in your mood, motivation levels, and even how you experience pleasure.

Up to 90% of Ozempic Users Experience an Adverse Event

The most common side effects linked to Ozempic and similar drugs are gastrointestinal, including nausea, diarrhea and vomiting. In clinical trials, a staggering 80% to 90% of participants experienced at least one adverse event.¹² Though most were mild to moderate, they led some people to discontinue the medication.

Further, these drugs are intended for long-term use — stopping them often results in weight regain — further increasing the risk of side effects over time. While nausea and diarrhea might seem manageable, more severe health risks, including pancreatitis, are a real concern. A study of 16 million patients found that those taking liraglutide or semaglutide had over nine times the risk of developing pancreatitis compared to those on other weight loss medications.¹³

The same study showed a four-fold increase in the risk of bowel obstruction and nearly four times the risk of gastroparesis (stomach paralysis). Gallbladder issues are another significant concern. Clinical trials revealed higher rates of gallstones and cholecystitis (gallbladder inflammation) in people taking these drugs.¹⁴

While rare, some patients required surgery for these complications. It’s also worth noting that these medications increase heart rate.¹⁵ There’s also the potential for aspiration during anesthesia. These drugs slow down stomach emptying, which means you may still have food in your stomach even after fasting for the recommended time before surgery. This increases the risk of aspiration pneumonia, a serious complication.

The FDA has also warned that Ozempic causes an intestinal blockage called ileus,¹⁶ which can lead to life-threatening complications if not treated promptly.

Another Ozempic Dark Side: Kidney Damage

Troubling reports of severe kidney problems due to Ozempic are also emerging. Research published in the Clinical Kidney Journal reported two patients experienced acute interstitial nephritis (AIN), a serious kidney inflammation, after starting semaglutide.¹⁷

One case even involved focal segmental glomerulosclerosis (FSGS), a type of kidney scarring. These findings suggest these drugs pose significant risks to your kidney health, especially if you have pre-existing kidney issues. The first case involved a 68-year-old woman with chronic kidney disease who started semaglutide for weight loss.

Within weeks, she developed severe nausea and vomiting, leading to a dramatic increase in her creatinine levels — a key indicator of kidney function. Even after stopping the medication, her kidney function worsened upon restarting it. A biopsy confirmed acute interstitial nephritis, likely triggered by semaglutide.¹⁸

The second case was even more alarming. A 49-year-old woman with no prior kidney issues developed severe swelling and protein in her urine after three months on semaglutide. Her kidney biopsy revealed not only AIN but also FSGS, a condition that can lead to kidney failure.

The study authors suggest that risk factors for these complications may include chronic kidney disease, advanced age, obesity and concurrent use of other medications that can affect the kidneys. A review of the FDA’s adverse event reporting system revealed 2,375 kidney-related events associated with GLP-1 drugs between 2010 and 2022.¹⁹

Acute kidney injury was the most common, accounting for nearly 59% of reports. Other reported issues included high blood pressure, electrolyte imbalances and, in rare cases, severe protein loss in the urine.

Akkermansia: A Natural Ozempic Alternative

Sustainable weight loss involves more than just a quick fix. It requires a holistic approach that considers your overall health, including your mental well-being. As tempting as these drugs might seem, especially with their popularity on social media, it’s crucial to make decisions based on scientific evidence rather than anecdotal reports or trends. Your health is too important to gamble with unproven or potentially dangerous solutions.

In my interview with Dr. Colleen Cutcliffe, a molecular biology scientist and the CEO and co-founder of Pendulum, a company that creates microbiome products, she explained that, instead of using Ozempic, you can naturally elevate your GLP-1 levels by increasing the presence of the beneficial bacteria Akkermansia in your gut:

“What happens in your body naturally, if you’ve got all the right microbes, is that you eat a meal, your microbiome metabolizes that food and generates postbiotics [excretions from beneficial bacteria] like butyrate [and] a protein called P9. Some of these postbiotics then signal your body to produce GLP-1.

All that signaling is happening from the microbiome directly to the L cells. And so you eat a meal, your microbiome digests them, these postbiotics get created and tell your L cells, ‘Hey, go produce GLP-1,’ and then you get a spike in GLP-1 in your body.

GLP-1 stimulates your body too. It says, ‘We’ve got to metabolize the sugar in the bloodstream, release insulin.’ It also signals to your brain, ‘We just ate, we’re full, we don’t need to eat again.’ After a period of time, GLP-1 goes down — until the next time you eat a meal. Then it spikes again.

So that’s the natural way of things. There are only two strains that have been published, to date, that have been shown to be able to stimulate L cells to produce GLP-1, and one of them is Akkermansia. It actually secretes three different [postbiotics] that stimulate L cells to produce GLP-1.

So, what’s been found is that if you are low or missing Akkermansia, your body is not naturally producing as much GLP-1 as it’s supposed to be. By giving people back Akkermansia, you can now have these physiological benefits of reducing A1C and lowering blood glucose spikes.

To be clear, the natural GLP-1 you produce is different from the drug. The drug is a mimic. It’s an analog. It looks like GLP-1. It gets injected into the bloodstream directly, which means that rather than the natural spike after you eat [followed by a decline], the [drug] is keeping those levels really high all the time.

So, this signaling of ‘we got to metabolize sugar in the blood and we’re full, we just ate’ is going on constantly. That’s why people experience these incredible, amazing overnight effects because that’s how those drugs are working. But if you actually have the right microbes, you can generate your body’s natural GLP-1 and get back into this natural cycle.”

Many People Are Lacking Akkermansia

Research published in Nature Microbiology found that Akkermansia increased thermogenesis and GLP-1 secretion in mice fed a high-fat diet.²⁰ While Akkermansia plays a vital role in maintaining intestinal health, many individuals have insufficient levels due to compromised mitochondrial function and oxygen leakage in the gut.

One of Akkermansia’s primary functions is the production of short-chain fatty acids (SCFAs), including butyrate. These fatty acids serve as fuel for your colonocytes, which in turn produce mucin, a gel-like protective substance that coats your gut lining.

SCFAs also help remove oxygen from your colon, creating an environment where beneficial bacteria can flourish. Mucin acts as a barrier, shielding intestinal cells from damage, harmful microorganisms and digestive irritants.

Additionally, mucin enhances your immune system. It contains antibodies and antimicrobial peptides that help fight infections. Mucin also functions as a trap for potential pathogens, facilitating their elimination through the digestive process. Akkermansia is so beneficial that it should, ideally, constitute about 10% of your gut microbiome.

Make Sure Live Akkermansia Probiotics Reach Your Colon

When selecting Akkermansia probiotics, opt for products with bacterial counts in the billions rather than millions. Generally, a higher bacterial count is beneficial, but there’s an important caveat: the delivery method is crucial.

Look for probiotics in delayed-release capsules. This feature is essential because it ensures the beneficial bacteria have a higher likelihood of reaching your colon alive. Without this protective mechanism, most of the bacteria may not survive the journey through your digestive system.

Akkermansia are very sensitive to oxygen. This makes their journey through your digestive system very challenging. These beneficial microbes thrive in an oxygen-free environment, and even a brief exposure to oxygen can be fatal for them. This trait makes the delivery method of Akkermansia supplements crucial to their effectiveness.

In fact, a lower-dose probiotic (in the hundreds of thousands of bacteria) that successfully reaches your colon can be more effective than a high-dose product (with hundreds of billions of bacteria) that doesn’t make it to its intended destination. Remember, when it comes to probiotics, successful delivery to the colon is just as important as the initial dosage.

Understanding this helps you choose the most effective supplement. You want to nurture your gut microbiome with live, active Akkermansia, as dead or inactive ones won’t do you as much good as they don’t reproduce.

If you want to use Akkermansia supplements, look for ones with advanced, dual-timed release capsules or microencapsulation. These technologies keep Akkermansia dormant and protected until it reaches your colon, usually in two to four hours.

To maximize its effectiveness, take it on an empty stomach, ideally first thing in the morning after an overnight fast. Wait at least one to two hours before eating to reduce transit time, allowing the bacteria to reach your colon faster — usually within two hours. This will greatly increase the number of live bacteria that make it to your colon.

Avoid taking probiotics with food, as this can extend your transit time to over eight hours, likely killing the bacteria long before they reach your colon. Being mindful of when and how you take your Akkermansia probiotic will maximize the benefits of this powerful probiotic.

• ^1, 8, 9 JAMA Netw Open. 2024 Aug 20;7(8):e2423385
• ^{2, 3, 4, 5, 6, 7} Daily Mail September 8, 2024
• ¹⁰ ZeroHedge August 21, 2024
• ¹¹ Front Psychiatry. 2023 Aug 29;14:1238353
• ^{12, 13, 14, 15} Obes Pillars. 2024 Aug 31;12:100127
• ¹⁶ U.S. FDA, Drug Safety-related Labeling Changes, Ozempic September 22, 2023
• ^17, 18, 19 Clin Kidney J. 2024 Aug 13;17(9):sfae250
• ²⁰ Nature Microbiology volume 6, pages 563–573 (2021)

(Mercola)—I’ve long been fascinated by cholesterol’s role in our health, and research published over the last few years challenges what we’ve been told for decades. For example, a groundbreaking study of over 23,000 people reveals surprising, never-before considered findings about the impact of race and genetics on cholesterol and its links to heart disease.

Is Lower Cholesterol Really a Good Thing?

You’ve been told that high cholesterol is bad and low cholesterol is good. But what if I told you that low cholesterol could actually harm your heart health? This might sound counterintuitive, but recent research has uncovered some surprising truths about cholesterol’s role in our bodies.

Cholesterol is a crucial component of cell membranes and a precursor to many important hormones.¹ It’s not just a harmful substance to be eliminated, but a vital part of our biology. In fact, cholesterol plays a key role in brain function, hormone production, and even vitamin D synthesis.

For decades, the medical community has focused on lowering cholesterol levels to prevent heart disease. This approach was based on studies like the Framingham Heart Study, which linked high cholesterol to increased cardiovascular risk. As a result, millions of people have been prescribed statins and told to follow low-fat diets.

However, new research is challenging this simplistic view. The REGARDS (REasons for Geographic and Racial Differences in Stroke) study² published in the Journal of the American College of Cardiology examined data from 23,901 participants over a median follow-up of 10.7 years.

The researchers found that the relationship between HDL cholesterol and heart disease risk actually varied depending on race. Low levels of high-density lipoprotein (HDL) cholesterol — often called “good” cholesterol — were only associated with increased risk of coronary heart disease in White adults. Even more surprisingly, high levels of HDL cholesterol didn’t seem to protect against heart disease in either White or Black adults.

This revelation challenges decades of medical advice that has emphasized raising HDL cholesterol levels as a way to improve heart health. It also highlights the importance of considering racial differences in health research and treatment recommendations.

Another intriguing discovery is the “cholesterol paradox” observed in various health conditions.³ In some cases, individuals with low cholesterol levels actually had worse health outcomes than those with higher levels — a finding that flies in the face of long-held beliefs about cholesterol and health. As noted in one 2023 scientific review:

“On average, patients with a total cholesterol level of 232 mg/dl had a 25% higher survival rate than those with a total cholesterol level of 193 mg/dl who were suffering from heart failure. A total cholesterol level under 200 mg/dl is generally preferred.”⁴

These unexpected results raise important questions about how we assess cardiovascular risk and whether current treatment guidelines are appropriate for all populations. Clearly, the relationship between cholesterol and health isn’t nearly as straightforward as we once thought.

Complex Interplay of Factors Influence Cholesterol’s Effects

Aside from race, individual genetics also play a big part in how our bodies handle cholesterol. Some people naturally make more cholesterol, while others make less. This is why two people eating the same diet can have very different cholesterol levels.⁵

Inflammation and oxidative stress in our bodies can also impact how cholesterol affects our health. When there’s a lot of inflammation, cholesterol can act differently and cause problems that would not occur in someone that did not have the same level of inflammation. This is one reason why overall health is so important when thinking about cholesterol.⁶

This complex web of interactions makes it hard to predict exactly how cholesterol will affect each person’s health.⁷ Here’s a short list of factors that influence cholesterol’s effects:

1. Cellular energy production
2. Genetic factors
3. Inflammation and oxidative stress
4. Interaction with other metabolic processes

Understanding these relationships helps explain why low cholesterol isn’t always good and high cholesterol isn’t always bad.

Shifting Paradigms in Cholesterol Management

The revelations about cholesterol’s complex role in health are causing waves across the medical community and beyond. Importantly, these findings are prompting a reevaluation of cholesterol treatment guidelines that have been in place for decades.⁸

Healthcare providers are increasingly moving towards a more personalized approach to cholesterol management. Instead of relying solely on total cholesterol numbers, doctors are considering a wider range of factors including race, genetics, and overall health status when assessing cardiovascular risk.⁹

The pharmaceutical industry may need to adapt to new understandings of cholesterol’s role in health. As research reveals the complex relationship between cholesterol levels and heart disease risk across different populations, drug development and marketing strategies really ought to shift to reflect more personalized approaches to cardiovascular health management.¹⁰ Whether that will actually happen remains to be seen.

Public health messaging about cholesterol is also undergoing a transformation. The old mantra of “lower is always better” is being replaced with more nuanced advice. Dietary recommendations are shifting away from blanket low-fat guidelines to focus on overall diet quality and individual metabolic health.¹¹

These changes are empowering patients to take a more active role in their health management. With a better understanding of cholesterol’s complexities, you can make more informed decisions about your diet, lifestyle, and medical treatments.

Advanced lipid testing methods that provide more detailed information about cholesterol particle size and number are becoming increasingly important. These tests offer insights beyond standard lipid panels, allowing for more accurate cardiovascular risk assessment and targeted interventions.¹²

As our understanding of cholesterol continues to evolve, it’s clear that its impact extends far beyond individual health. It’s reshaping medical practice, influencing public health policy, and even affecting economic sectors.

To better understand the real-world implications of these findings, let’s look at some specific examples and case studies that illustrate the complexity of cholesterol management in different scenarios.

Real-World Scenarios Illustrate Complexity of Cholesterol Management

Consider the case of John, a 55-year-old White male with low HDL cholesterol levels. Traditional medical wisdom would have flagged him as high-risk for heart disease, and indeed, the REGARDS study^{13,14,15,16,17} confirmed that that low HDL cholesterol is associated with increased risk in White adults. So, for someone like John, a White male, the traditional wisdom about low HDL cholesterol increasing heart disease risk holds true.

In contrast, Maria, a 60-year-old Black woman with high HDL cholesterol, might have been considered at low risk for heart disease based on outdated guidelines. However, the new research suggests that high HDL levels aren’t necessarily protective for Black adults, prompting a reevaluation of Maria’s overall cardiovascular health beyond just her cholesterol numbers.

Another intriguing example is seen in highly trained, keto-adapted athletes. These individuals often display what appears to be paradoxically high cholesterol levels, yet they maintain excellent cardiovascular health.¹⁸ This phenomenon highlights the complex interplay between diet, physical activity, and cholesterol metabolism.

These scenarios underscore the need for a more nuanced and individualized approach to cholesterol management. They demonstrate that relying solely on standard cholesterol numbers can lead to misclassification of risk and inappropriate treatment decisions.

Given these complex scenarios, what can be done to optimize cholesterol management and improve health outcomes? The answer lies in a more holistic and personalized approach to health assessment and treatment.

Advanced Strategies for Optimizing Cholesterol Health

The takeaway is that improving cholesterol health goes beyond simply lowering your total cholesterol levels. A comprehensive approach that considers individual factors and overall metabolic health is key. Here are some strategies to promote optimal cholesterol balance. By embracing a more holistic strategy, you and your healthcare provider can work together to reduce your cardiovascular health risks.

• Personalized risk assessment — Healthcare providers should look beyond standard cholesterol numbers and consider factors like race, age, genetics, and lifestyle when evaluating cardiovascular risk.¹⁹
• Advanced lipid testing — This provides a more detailed picture of cholesterol levels than standard tests. These tests break down different types of LDL and HDL particles, giving you a clearer understanding of your individual heart disease risk.²⁰ Importantly, this detailed information helps identify individuals at risk even when their standard lipid panel appears normal.²¹
• Diet — Instead of focusing solely on lowering fat intake, focus on the quality of fats consumed. Incorporating foods rich in omega-3s, and saturated fats such as butter and coconut oil, will help you maintain a healthy cholesterol level while supporting your overall heart health.
• Exercise — Regular physical activity, especially a combination of aerobic exercise and strength training, helps improve lipid profiles and overall metabolic health.²²
• Targeted supplementation — For some individuals, targeted supplementation might be beneficial. For example, nutrients like omega-3s, niacin, and plant sterols have shown promise in supporting healthy cholesterol levels.²³

Sources and References

• ^{1, 3, 4, 5, 6, 7, 10, 11, 12, 14, 18, 21, 22, 23} Int. J. Res. Ayurveda Pharm. 14(2), 2023
• ^{2, 8, 9, 13, 19, 20} Journal of the American College of Cardiology Volume 80, Issue 22, November 29, 2022, Pages 2104-2115
• ¹⁵ NBC News, November 22, 2022
• ¹⁶ Healio, November 21, 2022
• ¹⁷ Medical News Today, November 22, 2022

• In my recent appearance on The Jimmy Dore Show, we discussed how mitochondrial dysfunction, caused by modern toxins, is at the root of many diseases. ATP production has decreased by up to 75% compared to a century ago
• I shared insights from my latest book, “Your Guide to Cellular Health: Unlocking the Science of Longevity and Joy,” including that seed oils, like soybean and corn oil, are major culprits in damaging cellular health, while natural sugars can be beneficial when used wisely
• Endocrine-disrupting chemicals and EMFs from devices like cellphones and Wi-Fi routers pose significant risks to mitochondrial function, necessitating practical steps to reduce exposure
• Powerful foundations and industry interests have shaped medical education and public health policies, often prioritizing pharmaceutical interventions over natural approaches
• Restoring cellular health involves eliminating toxins, adopting a whole foods diet, optimizing sun exposure and addressing gut health imbalances

(Mercola)—In my recent appearance on The Jimmy Dore Show, we explored a vital yet often overlooked aspect of human well-being — cellular health and the myriad of silent toxins eroding it. I shared insights from my latest book, “Your Guide to Cellular Health: Unlocking the Science of Longevity and Joy.”

This article reviews the most pivotal points from our extensive discussion, revealing the vital components that sustain health and the modern challenges that threaten them. As I shared with Dore, for 15 years I struggled with a mind-bending, unexplained rash that caused me to lose sleep at night because of unrelenting itching. All the physicians I consulted, some of the best out there, had no clue how to resolve it.

This personal battle led me to a groundbreaking realization: impaired mitochondrial function is at the heart of nearly every disease. Mitochondria, the powerhouses of your cells, produce adenosine triphosphate (ATP) — your body’s essential energy currency.

Everyone knows you can’t run a car without fuel. Similarly, your body is a vehicle that transports you around, and if you don’t have enough energy, it’s a problem. Historically, humans produced twice the amount of ATP compared to today, but the influx of chemical toxins has drastically reduced cellular energy production, leading to a significant decline in overall health.

The ATP Crisis: A Modern Epidemic

Humans are producing up to 75% less ATP today than a century ago. This decline is not just a number — it’s a reflection of our deteriorating health. The question remains: Why has ATP production plummeted?

The answer lies in the toxins that have permeated our environment over the past 150 years. The Industrial Revolution and subsequent advancements introduced chemical poisons into our lives, fundamentally disrupting our cellular machinery. Among these toxins, seed oils like soybean, corn and sunflower oil, stand out as primary culprits in harming your cellular energy.

Seed Oils: The Silent Destroyers of Health

Seed oils rich in polyunsaturated fatty acids (PUFAs) are one of the main drivers destroying your health, as excess consumption leads to obesity, diabetes, heart disease, cancer and dementia. These oils, often misleadingly labeled as “healthy” vegetable oils, wreak havoc on mitochondrial function. Consuming excessive amounts overloads your cells with harmful fats, crippling their ability to produce ATP.

Safe alternatives include coconut oil, ghee and beef tallow. Eating out poses a significant challenge for those striving to avoid seed oils like canola and soybean oil. One practical tip when you dine at a restaurant is to inform the server that you have a severe allergy to seed oils. Show them evidence of the dangers, and ensure the kitchen adheres to your requirements.

Most restaurants are unaware of the extent of seed oil contamination. By educating them and insisting on pure fats, you protect your health while raising awareness. The prevalence of adulterated oils, even in the case of products like extra virgin olive oil, makes vigilance essential. Additionally, cooking your own meals at home or choosing restaurants that use healthier frying fats, such as beef tallow, will significantly reduce your exposure to harmful PUFAs.

The Truth About Sugar: A Cellular Fuel

Contrary to popular belief, not all sugars are detrimental. Sugar, when used wisely, restores your energy. The key lies in understanding the type of sugar and its role in your metabolism. Real sugar — specifically glucose, also known as dextrose — is the ultimate fuel for your mitochondria. Unlike high-fructose corn syrup, which is harmful, glucose is essential for efficient energy production.

However, moderation is crucial. If you consume too much sugar, it disrupts insulin and hormonal balance. For individuals suffering from severe mitochondrial poisoning, however, glucose is a lifesaver, providing the necessary energy to sustain vital bodily functions. This nuanced understanding of sugar’s role challenges the conventional narrative that all carbohydrates are harmful.

Your Gut Microbiome: Balancing Good and Bad Bacteria

Your gut health plays a pivotal role in cellular energy and overall well-being. I explained the importance of colonocytes — cells lining your colon that rely on short-chain fatty acids like butyrate, propionate and acetate, produced by beneficial bacteria. When mitochondrial function is impaired, these colonocytes begin to die, allowing oxygen to seep back into your gut.

This shift creates an environment where pathogenic, oxygen-tolerant bacteria thrive, producing endotoxins that further damage mitochondria. This creates a vicious cycle I call the “black hole of death.”

To break free from this cycle, it’s essential to restore the balance of gut bacteria. Unfortunately, many people are unaware of the state of their microbiome, as beneficial bacteria are often overshadowed by their pathogenic counterparts. Advanced testing, though expensive, provides insights into the state of your gut health, but practical dietary adjustments are equally important.

Until an intervention targets the factors harming your colonocytes and restores optimal oxygen levels, the population of beneficial, oxygen-intolerant microbes cannot be reestablished in your gut. This mitochondrial-gut microbiome communication is necessary for health. However, when oxygen-tolerant pathogenic bacteria dominate, they outcompete the beneficial, oxygen-intolerant bacteria, preventing the production of essential metabolites needed for vitality.

Removing excess oxygen from your colon is key because, without it, even the best lifestyle practices — such as exercise, adequate sleep proper nutrition and the use of supplements — will not result in significant improvement. Simply introducing probiotics is insufficient for replenishing oxygen-intolerant microbes, as most commercially available probiotics are often non-viable.

While these probiotics offer postbiotic benefits, they do not function as true “seeds” to rebuild the appropriate microbial community. Just as a seed cannot grow in a desert, the environment within your colon must be conducive for these beneficial microbes to flourish.

Therefore, avoiding mitochondrial poisons, including seed oils and endocrine-disrupting chemicals, is essential to create the right conditions for restoring a healthy, oxygen-intolerant microbial population in your gut.

The Hidden Dangers of Plastics and Endocrine Disruptors

Beyond dietary choices, environmental toxins like plastics pose a significant threat to cellular health. Plastics produce endocrine-disrupting chemicals (EDCs) that stimulate estrogen receptors. These chemicals are pervasive, found in everyday items like water bottles and food wraps, and are linked to various health issues, including breast cancer.

EDCs disrupt hormonal balance, leading to widespread health problems. These chemicals primarily operate by activating estrogen receptors within your cells. This activation leads to an increased influx of calcium ions into your cells. Excessive intracellular calcium dramatically elevates the levels of superoxide and nitric oxide.

These reactive molecules swiftly combine to form peroxynitrite, an extremely potent oxidant stressor. The formation of peroxynitrite induces severe oxidative stress, resulting in significant cellular damage. In addition, when combined with natural estrogen, exposure to EDCs leads to estrogen overload and initiates a series of harmful events.

How EDCs Trigger Your Self-Attack Autoimmune Responses

Endocrine-disrupting chemicals (EDCs) pose a significant threat to your health, initiating a cascade of negative effects that begin at the cellular level and ripple outward to impact your entire body. This process unfolds in several interconnected stages, each building upon the last to create a perfect storm of health challenges in your system.

It all starts with your mitochondria — the powerhouses of your cells. EDCs interfere with these crucial organelles, diminishing their ability to produce the energy your cells need to function optimally. This energy deficit isn’t just a matter of you feeling tired; it has far-reaching consequences, particularly for your gut health.

Your digestive system relies on a delicate balance of beneficial bacteria, many of which thrive in an oxygen-free environment. The energy shortage caused by mitochondrial dysfunction disrupts this carefully maintained anaerobic setting in your gut. As a result, these beneficial microorganisms struggle to survive and perform their vital functions within you.

One of the key roles of these gut bacteria is the production of short-chain fatty acids. These compounds are essential for maintaining the health and integrity of your intestinal lining. They act as a primary food source for the cells that make up this barrier and help regulate the immune responses in your gut. However, when your gut bacteria are compromised due to the altered environment, their ability to produce these crucial fatty acids is severely impaired.

The absence of adequate short-chain fatty acids leads to a weakening of your intestinal barrier. This condition is often referred to as “leaky gut” or increased intestinal permeability. In this state, the tight junctions between the cells lining your intestines become loose, allowing substances that should remain within your gut to pass into your bloodstream.

This is where the situation can take a particularly concerning turn for you. Among the substances that can now penetrate your weakened gut barrier are proteins that bear a striking resemblance to structures within your own body — such as those found in your joints or neurological tissues.

When these foreign yet familiar proteins enter your bloodstream, your immune system is faced with a case of mistaken identity. It perceives these proteins as threats and mounts an attack against them.

The problem is, due to the similarity between these intruding proteins and your own body tissues, your immune response doesn’t stop at neutralizing the perceived invaders. Instead, it can turn against your own cells and tissues that share similar structures. This misdirected immune attack is the hallmark of autoimmune diseases, where your body essentially wages war against itself.

Thus, from the initial disruption of cellular energy production by EDCs, you arrive at a situation where your body’s own defense mechanisms have been tricked into causing harm to you. This complex chain of events underscores the far-reaching and interconnected nature of your body’s systems and highlights how these seemingly small disruptions can cascade into significant health challenges for you.

The challenge lies in finding safe alternatives, as conventional plastics are laden with harmful chemicals. I’m in the process of creating bio-compatible alternatives to plastics in order to help eliminate EDC exposure and promote environmental sustainability.

Electromagnetic Fields (EMFs): A Mitochondrial Poison

Another insidious threat to your cellular health today is exposure to EMFs. Unlike other toxins, EMFs permeate our environment, making them a pervasive danger that is often overlooked.

Electromagnetic frequencies describe all types of radiation, including beneficial ones like sunlight. However, the high-frequency EMFs emitted by modern devices such as cellphones, Wi-Fi routers and microwaves operate in the gigahertz range, posing significant risks to your mitochondria.

While ionizing radiation like X-rays directly damages cells by creating free radicals, EMFs cause harm through a different mechanism called non-thermal effects. These non-thermal effects disrupt cellular function without raising tissue temperatures, making the damage less visible but equally, if not more, dangerous.

EMFs interfere with mitochondria by increasing calcium ion influx into cells. Elevated calcium levels catalyze the production of harmful free radicals, leading to oxidative stress and mitochondrial dysfunction. This process mirrors the damage caused by other mitochondrial poisons, like seed oils and EDCs, creating a vicious cycle of cellular decline.

The Telecommunication Industry’s Deceptive Practices

The telecommunications industry, much like the tobacco industry before it, has employed deceptive strategies to downplay the dangers of EMFs. They used the same playbook as the tobacco industry to greenwash their products and obfuscate the real risks. The 1996 Telecommunications Act, for instance, effectively immunized these companies from liability, allowing them to continue disseminating harmful EMFs without accountability.

They promote the idea that non-ionizing radiation is safe because it doesn’t cause immediate thermal damage. This misleading narrative ignores the long-term, chronic effects of EMF exposure, which accumulate over time and contribute to a host of health problems, including cancer, neurological disorders and reduced cellular energy.

Practical Steps to Mitigate EMF Exposure

Understanding the dangers of EMFs is only the first step; taking actionable measures to reduce exposure is crucial for safeguarding your health. Here are several strategies I recommend:

1. Limit cellphone use — Avoid keeping your cellphone close to your body, especially when sleeping. Cellphones emit high levels of EMFs and prolonged exposure significantly disrupts mitochondrial function. I personally use an EMF shield tent to create a low-radiation environment during sleep, ensuring that my mitochondria remain untainted by these frequencies.
2. Reduce Wi-Fi dependency — Turn off Wi-Fi routers when not in use, especially at night. Wi-Fi is a constant source of EMFs in many households, and minimizing its operation drastically reduces overall exposure. For essential connectivity, use wired Ethernet connections instead of wireless alternatives.
3. Create EMF-free zones — Designate certain areas of your home, such as your bedroom, as EMF-free zones. By establishing a sanctuary free from electromagnetic radiation, you provide your mitochondria with the environment they need to function optimally. Simple steps like using wired devices and keeping electronic gadgets out of these areas makes a significant difference.
4. Use EMF shielding products — Investing in EMF shielding products, such as EMF-blocking phone cases or shielding tents, provides additional protection. These products help deflect or absorb harmful frequencies, safeguarding your cellular health. While not a complete solution, they offer a practical layer of defense against unavoidable EMF exposure.

Reclaiming Health: Strategies for Protection and Restoration

To break free from this cycle of mitochondrial poisoning, it is imperative to adopt comprehensive strategies that eliminate exposure to harmful toxins and support mitochondrial function. Here are several actionable steps:

1. Eliminate seed oils and processed foods — As mentioned, seed oils like soybean, corn and sunflower oil are laden with PUFAs that oxidize easily, producing toxic metabolites that damage mitochondria. By removing these oils from your diet, you reduce the primary source of mitochondrial poisoning.
2. Adopt safe fats and whole foods — Incorporate saturated fats such as coconut oil, butter, ghee and beef tallow into your diet. These fats are stable and support mitochondrial function without the harmful effects of PUFAs. Additionally, focus on whole, unprocessed foods that provide essential nutrients without the added toxins found in processed products.
3. Minimize EMF exposure — Limit your exposure to EMFs by reducing the use of wireless devices and turning off Wi-Fi when not in use. Embracing EMF shielding solutions, such as EMF-blocking phone cases and creating EMF-free zones in your home, significantly reduces cellular stress and supports mitochondrial health.
4. Optimize sun exposure — Embrace sun exposure around solar noon once you have eliminated seed oils from your diet. Proper sun exposure enhances mitochondrial energy production and supports overall health. Use minimal, protective clothing to maximize benefits while preventing skin damage.
5. Restore gut health — Addressing gut microbiome imbalances is crucial for maintaining cellular energy. Focus on consuming beneficial bacteria and limiting fiber intake if pathogenic bacteria dominate your gut. Probiotic supplements and dietary adjustments help restore a healthy balance of gut flora, supporting mitochondrial function.

The Power of Education and Advocacy

Raising awareness about the true impact of these mitochondrial poisons is essential for empowering individuals to take control of their health. Education and advocacy are crucial in countering the misinformation spread by powerful industries. By informing the public about the real dangers of seed oils, EMFs and mask mandates, we foster a movement toward healthier living and systemic change.

On an individual level, you must take proactive steps to protect your health, even in the face of pervasive EMF exposure and misleading public health directives. Simple lifestyle changes, combined with a commitment to natural health principles, significantly enhance mitochondrial function and overall well-being.

A Vision for a Healthier Future

Looking ahead, my mission is to continue developing solutions that protect and restore cellular health. These efforts aim to harmonize technological advancements with natural health practices, ensuring that progress does not come at the expense of our well-being.

The goal is to empower individuals with the knowledge and tools needed to maintain robust mitochondrial function and achieve lasting health. By addressing the root causes of mitochondrial poisoning and advocating for informed, holistic health practices, we’ll can pave the way for a future of longevity and joy.

Food goes beyond providing energy — it’s essential for proper nutrition. Yet, many people fail to get the essential micronutrients they need. The problem often lies in food quality rather than quantity. People are consuming energy-dense, nutrient-poor foods, setting them up for an excess of omega-6 fats from seed oils as well as added sugars, while missing out on vital micronutrients.

Micronutrient deficiencies are a prevalent form of malnutrition, leading to serious consequences like pregnancy complications, weakened immunity and increased risk of diseases. While past studies have investigated nutrient deficiencies and supplies, there has been no comprehensive global assessment of micronutrient intake inadequacies until now.

A recent study published in The Lancet Global Health¹ addresses this gap by evaluating whether current intake levels meet recommended health standards, focusing on deficiencies across different ages and genders. Their findings highlight an alarming trend — over half of the global population is deficient in the necessary micronutrients for optimal health.

Global Study Reveals Alarming Widespread Micronutrient Inadequacies

The study,² conducted by researchers at Harvard T.H. Chan School of Public Health and the University of California, Santa Barbara (UCSB), used data from 31 countries to model global nutrient needs. They applied these models to a dataset from 185 countries, estimating nutrient deficiencies for 99.3% of the world’s population. Fifteen essential nutrients, including calcium, B vitamins and vitamin C, were evaluated across different age and gender groups.

“Our study is a big step forward,” said co-lead author Christopher Free, Ph.D., a research professor at the University of California, Santa Barbara (UCSB), in a news release.³ “Not only because it is the first to estimate inadequate micronutrient intakes for 34 age-sex groups in nearly every country, but also because it makes these methods and results easily accessible to researchers and practitioners.” According to the authors:⁴

“More than 5 billion people do not consume enough iodine (68% of the global population), vitamin E (67%) and calcium (66%). More than 4 billion people do not consume enough iron (65%), riboflavin (55%), folate (54%) and vitamin C (53%).

Within the same country and age groups, estimated inadequate intakes were higher for women than for men for iodine, vitamin B12, iron and selenium and higher for men than for women for magnesium, vitamin B6, zinc, vitamin C, vitamin A, thiamin and niacin.”

These results underscore the widespread nature of micronutrient deficiencies globally, revealing distinct patterns related to sex and geographic location. “We hope this analysis … improves understanding of global micronutrient inadequacy so that public health interventions can more effectively address deficiencies,” the researchers concluded.

Common Nutrient Deficiencies in the US

According to data from the National Health and Nutrition Examination Surveys (NHANES), an estimated 31% of the U.S. population is at risk of developing one or more micronutrient deficiencies.⁵ The most common nutrient deficiencies include vitamins D, B1, B2, B3 and B12, A, C, E, calcium, magnesium and iodine.

Although the study didn’t include vitamin D since it primarily focused on nutrients obtained through diet, vitamin D deficiency remains a significant concern in the U.S., impacting approximately 35% of the population.⁶ Vitamin D is a fat-soluble vitamin that is essential for various physiological functions, including calcium absorption, bone health and immune function.

While it’s found naturally in some foods, your body endogenously produces vitamin D when your skin is exposed to ultraviolet rays from the sun.

However, many factors limit this natural production, including living in northern latitudes, having darker skin, spending most time indoors or using sunscreen. Additionally, as people age, their skin becomes less efficient at producing vitamin D from sun exposure.⁷

The ideal way to increase your vitamin D levels is through sensible sun exposure. On a typical sunny day,⁸ your body produces up to 25,000 international units IU of vitamin D. However, it’s important to approach sun exposure with care, especially if your diet is high in seed oils (rich in linoleic acid, or LA).

These oils migrate to your skin and oxidize when exposed to sunlight, causing inflammation and DNA damage, which makes you more prone to sunburn. If you’re on a high-LA diet, I recommend avoiding intense sun exposure until you’ve reduced your seed oil intake for four to six months. As you reduce your LA intake, slowly increase your time outdoors. You’ll eventually be able to enjoy an hour or more during peak sunlight hours.

If you’re unable to get adequate sun exposure, vitamin D3 supplementation is a wise choice. For health and disease prevention, aim for a level between 60 ng/mL and 80 ng/mL. In Europe, the measurements you’re looking for are 150 to 200 nmol/L, respectively.

To determine how much vitamin D3 you need to take, measure your vitamin D level, ideally twice a year. Your ideal dose is whatever it takes to keep you within that 60 ng/mL to 80 ng/mL range. It’s also important to remember that calcium, vitamin D3, magnesium and vitamin K2 must be properly balanced, as these four nutrients work together.

Vitamin B1, B2 and B3

Vitamin B1, also known as thiamine, is used by nearly all your cells and is essential for several functions in the body, including energy production, nerve function, heart health, cognition, digestion and immune function.⁹

While thiamine deficiency is often the result of alcohol misuse, chronic infections, poor nutrition and/or malabsorption, research suggests vitamin B1 availability has dramatically declined throughout the food chain in recent years,¹⁰ and that naturally affects your ability to get sufficient thiamine from your diet.

Adult men and women need 1.2 and 1.1 milligrams (mg), respectively, each day.¹¹ If you have symptoms of thiamine deficiency, you might need higher doses. For tips on how to boost your vitamin B1 levels, I recommend reading my article, “Common Signs of Vitamin B1 Deficiency.”

Similarly, vitamin B2, commonly known as riboflavin, is important for energy production, cellular function and metabolism. As a coenzyme in various redox reactions, riboflavin is essential for converting food into usable energy. It plays a central role in the electron transport chain, where it helps produce ATP, the primary energy source for the body. This makes riboflavin particularly important for overall energy levels and metabolic health.^12,13

To increase your riboflavin levels, consume a diet rich in riboflavin sources. Good dietary sources include grass fed dairy products, lean meats like grass fed beef tenderloin, organic low-PUFA eggs, cremini and portabella mushrooms, and green leafy vegetables like spinach and beet greens.

Vitamin B3 exists in two primary forms — niacin (nicotinic acid) and niacinamide (nicotinamide). Both are essential to human health and play important roles in cellular metabolism, converting the food you eat into energy.

These forms of vitamin B3 also serve as precursors for the coenzymes nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP), which are vital for energy production, DNA repair and cell signaling.

For optimal health, I recommend taking 50 mg of niacinamide three times a day. This dosage has been shown to optimize energy metabolism and boost NAD+ levels.

The problem with taking too much vitamin B3, whether in the form of niacin or niacinamide, is that it might backfire and contribute to cardiovascular disease as demonstrated in a study conducted by the Cleveland Clinic.¹⁴ I talked more about this in my article, “Vitamin B3 Boosts Muscle Mass, Improves Glucose Control.” As for food sources, vitamin B3 is found in grass fed beef and beef liver, bananas and mushrooms.¹⁵

Vitamin B12

Also known as cobalamin, vitamin B12 is a water-soluble vitamin that plays a role in numerous biochemical reactions and neurological functions in your body, including DNA synthesis. Your body can’t make vitamin B12 on its own, so it must be obtained via your diet or supplementation.¹⁶

According to NHANES data, about 3.6% of U.S. adults aged 19 and older have a vitamin B12 deficiency, with the rate slightly increasing to 3.7% in those 60 and older. However, vitamin B12 insufficiency is more common, affecting around 12.5% of adults aged 19 and older and 12.3% of those 60 and older. During pregnancy, vitamin B12 levels often decrease, sometimes falling below normal levels.¹⁷

Vitamin B12 is found almost exclusively in animal foods, such as grass fed beef and beef liver, lamb, organic eggs and grass fed dairy products. The few plant foods that are sources of B12 are actually B12 analogs that block the uptake of true B12, so do not make the mistake of thinking you can rely on vegan sources for all your B12 needs.

If you rarely eat the foods listed, consider using nutritional yeast. It’s high in B12 and has a cheesy flavor that works well on any number of dishes. One 16-gram serving (just over 2 tablespoons) provides 24 micrograms of natural vitamin B12.¹⁸ Advancing age diminishes your body’s ability to absorb B12 from food, so you might want to consider supplementation as you get older.¹⁹

Vitamins A and C

An estimated 51% of adults are not consuming enough vitamin A,²⁰ increasing their risk of degenerative diseases like macular degeneration, a leading cause of blindness in the U.S.²¹ Vitamin A is also responsible for immune system function as well as cellular growth and differentiation.²²

Vitamin A is a group of nutrients that falls into two different categories — retinoids found in animal foods and carotenoids found in plant foods. The two are chemically different and provide different health benefits, but both are necessary for optimal health. Plant foods high in beta-carotene include sweet potatoes, carrots, cantaloupe and mangoes. Animal foods rich in vitamin A include liver, egg yolks and grass fed butter.²³

Vitamin C, also known as ascorbic acid, is known for its potent antioxidant properties and role in numerous bodily functions, including tissue growth and repair, collagen synthesis, iron absorption and immune function.²⁴

A wide variety of foods are high in vitamin C, including red pepper, parsley, broccoli, kiwi, strawberries, guava, tomato and all citrus fruits. You’ll get significant amounts of vitamin C from your diet if you eat these foods on a daily basis.

In addition to dietary sources, I highly recommend keeping liposomal vitamin C in your medicine cabinet, particularly for acute viral illnesses. If I were to become acutely ill, I would take 4 grams of liposomal vitamin C every hour until feeling better, then start decreasing the dosage slowly over a few days once symptoms improve.

Vitamin E

Vitamin E is a fat-soluble vitamin with potent antioxidant properties, protecting your cells from free radical damage. It also supports the production of red blood cells, regulates your body’s use of vitamin K (which is important for heart health) and is involved in your immune function and cell signaling.²⁵ Additionally, it protects your body against damage caused by linoleic acid and estrogen.

In the U.S. alone, approximately 88.5% of the population fails to reach the recommended dietary allowance (RDA) of vitamin E.²⁶ To increase vitamin E levels, eat foods rich in this nutrient, including spinach, pumpkin, asparagus, red bell peppers, tomatoes, kiwi and mango.²⁷

Some health authorities recommend vegetable oils, seeds and nuts as good sources,²⁸ but these are actually terrible due to their high LA content. Beans — another good source of vitamin E — are also problematic for many due to their high lectin content.

Supplementation is also an option to increase your levels, but it’s important to look for a real vitamin E supplement and not synthetic. What you’re looking for is “d alpha tocopherol.” I go into detail about this in “Vitamin E Helps Decrease Your Cancer Risk.”

Calcium and Magnesium

Over 40% of the U.S. population fails to meet their calcium needs through diet alone, putting them at increased risk of bone-related issues such as osteoporosis and fractures.²⁹ Calcium is also essential for muscle contraction, nerve transmission and blood clotting.³⁰

A deficiency in calcium coupled with excess phosphorus intake due to phosphate additives in processed food poses additional risk, as it disrupts your calcium-to-phosphorus ratio, which leads to calcification of the vascular system and cardiovascular problems.³¹

Some good dietary sources of calcium to increase your levels include grass fed dairy products like yogurt, milk and cheese made from animal rennet. Some vegetables contain this mineral as well, such as collard greens, spinach, turnip greens, kale, cooked taro root and bok choy.³²

Estimates suggest that over half of the U.S. population also aren’t getting enough magnesium from their diet.³³ While the minimum amount needed to avoid deficiency is about 150 to 180 milligrams per day, optimal levels are closer to 600 milligrams per day. For reference, the RDA ranges from 310 to 420 milligrams per day, depending on age and sex.³⁴

Some good dietary sources of magnesium include dark chocolate, leafy greens, potatoes (peeled and boiled) and plain organic yogurt, to name a few. Avocados are also commonly recommended as a good source of this mineral, but they’re high in monounsaturated fat (MUFAs), which harms your metabolic function if consumed in excess.

Iodine

Iodine is an essential trace mineral that plays a role in the production of thyroid hormones, which regulate metabolism, growth and development. Adequate iodine intake is vital for maintaining healthy thyroid function and reducing the risk of disorders such as goiter and hypothyroidism. In addition, iodine is important for healthy bone and brain development during pregnancy and infancy.³⁵

Foods that contain higher amounts of iodine include sea vegetables, such as kelp, kombu and wakame.³⁶ Kelp has the highest amount of any food and just one serving gives you four times the recommended daily allowance. Organic, grass fed butter is another good source of iodine. Iodized salt also increases your levels if you don’t avoid eating it in the mistaken belief that it’s bad for your heart.

Will Taking a Multivitamin Help with Nutrient Deficiencies?

A diet rich in whole, nutrient-dense foods is key to avoiding nutrient deficiency. However, multivitamins help address gaps if you’re not eating right or if you suspect you have deficiencies. Research³⁷ from Oregon State University found that older men who took multivitamins showed improved nutritional biomarkers compared to those who took a placebo.

In fact, some participants in the placebo group had decreased nutrition markers, indicating that diet alone might not be sufficient, particularly for maintaining vitamin and carotenoid levels.³⁸ Multivitamins also benefit memory in older adults. One study³⁹ found that daily use could improve memory performance comparable to reversing about three years of age-related decline compared to a placebo.

If you’re planning to take multivitamins, it’s generally recommended to take half your daily dose in the morning, with breakfast, and the other half with your main meal. Remember, though, that multivitamins should complement, not replace, a healthy diet.

Dietary supplements are meant to support a balanced lifestyle, not substitute for it. Consider consulting with a holistic health professional to identify specific nutrient deficiencies and tailor your supplement and food choices to address them.

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• ³ EurekAlert! August 29, 2024
• ⁵ The Institute of Functional Medicine, The Hidden Hunger: Micronutrient Deficiencies
• ⁶ StatPearls [Internet]. Vitamin D Deficiency
• ⁷ Endocrine. 2023; 79(1): 31–44
• ⁸ Journal of Steroid Biochemistry and Molecular Biology, 2019;189
• ⁹ Biosci Rep. 2023 Oct 31;43(10):BSR20230374
• ¹⁰ The Science Times January 31, 2021
• ¹¹ NIH Thiamin, February 9, 2023
• ¹² NIH ODS, Riboflavin
• ¹³ StatPearls [Internet]. Biochemistry, Oxidative Phosphorylation
• ¹⁴ Nature Medicine volume 30, pages 424–434 (2024)
• ¹⁵ Harvard T.H. Chan School of Public Health, Niacin – Vitamin B3
• ¹⁶ StatPearls [Internet]. Vitamin B12 (Cobalamin)
• ¹⁷ Harvard T.H. Chan School of Public Health, Riboflavin — Vitamin B2
• ¹⁸ USDA FoodData Central, Nutritional Yeast
• ¹⁹ The New York Times, Vitamin B12 as Protection for the Aging Brain
• ²⁰ Oregon State University, Micronutrient Inadequacies, Vitamin A
• ²¹ Front Nutr. 2022; 9: 914457
• ^22, 23 NIH ODS, Vitamin A and Carotenoids
• ²⁴ StatPearls [Internet]. Vitamin C (Ascorbic Acid)
• ^25, 28 NIH ODS, Vitamin E
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• ³¹ Arterioscler Thromb Vasc Biol. 2024 Mar;44(3):584-602
• ³² Dietary Guidelines for Americans, Food Sources of Calcium
• ³³ Oregon State University, Micronutrient Inadequacies (Magnesium)
• ³⁴ National Institutes of Health, Magnesium
• ^35, 36 NIH ODS, Iodine
• ³⁷ Nutrients 2023, 15(12), 2691; doi: 10.3390/nu15122691
• ³⁸ Oregon State University June 14, 2023
• ³⁹ The American Journal of Clinical Nutrition July 2023, Volume 118, Issue 1, Pages 273-282, Results

At least according to one registered dietitian nutritionist in Los Angeles, who recently took to Fox News to lay out the risks from ultra-processed foods in the American diet.

Ilana Muhlstein said on Fox news that America’s diet is 60% ultra-processed, but that kids consume even more than that.

“With children, it’s actually over 70%. That is really wild when you think about it,” she said. “What we eat defines how our cells work, how our organs work, and we’re seeing a strong decline in mental health and well-being.”

And a recent BMJ study found that 60% of Americans’ daily calories come from ultra-processed foods (UPFs), which are linked to 32 poor health outcomes, including mental, respiratory, cardiovascular, and metabolic issues like cancer, heart disease, and type 2 diabetes, according to Fox.

Muhlstein added: “We’re actually seeing that this next generation might be the first generation to … have a shorter lifespan than their parents due to nutrition and lifestyle factors.”

A nutritious diet boosts children’s mental well-being, behavior, and academic performance, says Muhlstein, a nutritionist and instructor of “Raising Balanced Eaters.”

While cutting ultra-processed foods entirely is unrealistic, Muhlstein advocates for reversing the typical 70/30 ratio of processed to whole foods, recommending an “80/20 rule”—80% whole foods like eggs, fish, and vegetables, and 20% indulgent foods like chips and ice cream.

For healthier options, Muhlstein suggests swapping ketchup for marinara sauce on chicken nuggets and fries, opting for chicken strips over mechanically processed nuggets, and choosing hamburgers over nitrite-laden hot dogs. Each small change reduces the overall level of food processing.

The nutritionist warns that poor eating habits won’t resolve on their own and encourages exposing kids to diverse flavors and textures early on.

The Fox News report says that sitting down for family meals—without screens—can reduce the risk of eating disorders and promote a healthy relationship with food. Just three to five family meals a week can make a positive difference, fostering better eating habits and family connection.